肥胖和非肥胖 2 型糖尿病及非糖尿病患者血清成纤维细胞生长因子 19 水平与代谢因素的关系：一项病例对照研究。

Relationship between the levels of serum fibroblast growth factor 19 and metabolic factors in obese and normal weight subjects with and without type 2 diabetes mellitus: a case-control study.

机构信息

Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.

Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Horm Mol Biol Clin Investig. 2021 Feb 1;42(1):11-17. doi: 10.1515/hmbci-2020-0075.

DOI:10.1515/hmbci-2020-0075

PMID:33544512

Abstract

OBJECTIVES

Fibroblast growth factor 19 (FGF-19) is a metabolic regulating factor with an anti-diabetic effect. This study aimed to evaluate FGF-19 in patients with type 2 diabetes mellitus (T2DM) and its relationship with some metabolic risk factors.

METHODS

In this case-control study, 80 diabetic patients and 80 non-diabetic individuals were divided into two subgroups based on body mass index (BMI): obese people (BMI≥30) and participants with normal weight (25>BMI≥18.5). Furthermore, stratified analysis by gender was also performed. The metabolic factors were measured and compared in all groups. The relationship between FGF-19 and the measured items was investigated in each group.

RESULTS

The FGF-19 levels did not show a significant difference between groups. The serum levels of FGF-19 were negatively associated with some metabolic items, such as BMI, low-density lipoprotein (LDL), total cholesterol (TC) (p<0.01), and LDL/high-density lipoprotein (HDL) ratio (p=0.02) only in the healthy group with normal weight. According to the gender-based classification of individuals, FGF-19 showed a significant inverse relationship with BMI, weight (WT), waist circumference (WC), and hip circumference (HC) (p<0.05) in diabetic men; besides, FGF-19 in non-diabetic women had a significant negative association with TC, LDL, and LDL/HDL ratio (p<0.05).

CONCLUSIONS

The levels of FGF-19 were negatively correlated to WT, BMI, WC and HC in diabetic males. More studies are needed to warrant these results.

摘要

目的

成纤维细胞生长因子 19（FGF-19）是一种具有抗糖尿病作用的代谢调节因子。本研究旨在评估 2 型糖尿病（T2DM）患者的 FGF-19 及其与一些代谢危险因素的关系。

方法

在这项病例对照研究中，根据体重指数（BMI）将 80 名糖尿病患者和 80 名非糖尿病个体分为两组：肥胖者（BMI≥30）和体重正常者（25>BMI≥18.5）。此外，还按性别进行了分层分析。测量并比较了所有组的代谢因素。在每组中研究了 FGF-19 与测量项目之间的关系。

结果

各组之间的 FGF-19 水平没有差异。FGF-19 的血清水平与一些代谢指标呈负相关，例如 BMI、低密度脂蛋白（LDL）、总胆固醇（TC）（p<0.01）和 LDL/高密度脂蛋白（HDL）比值（p=0.02），仅在体重正常的健康组中。根据个体的性别分类，在糖尿病男性中，FGF-19 与 BMI、体重（WT）、腰围（WC）和臀围（HC）呈显著负相关（p<0.05）；此外，非糖尿病女性的 FGF-19 与 TC、LDL 和 LDL/HDL 比值呈显著负相关（p<0.05）。