产前暴露于对乙酰氨基酚会增加儿童特应性皮炎的风险：台湾的一项全国性巢式病例对照研究。

Prenatal exposure to acetaminophen increases the risk of atopic dermatitis in children: A nationwide nested case-control study in Taiwan.

机构信息

Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.

School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

出版信息

Pediatr Allergy Immunol. 2021 Jul;32(5):1080-1088. doi: 10.1111/pai.13465. Epub 2021 Mar 8.

DOI:10.1111/pai.13465

PMID:33544946

Abstract

BACKGROUND

Acetaminophen (APAP) has been associated with the development of atopic diseases. However, little is known about the relationship between prenatal APAP exposure and atopic dermatitis (AD) in offspring.

OBJECTIVE

To investigate the association between prenatal APAP exposure and AD risk in offspring.

METHODS

In this study, 2029 study pairs (AD-affected children and their mothers) and 5,058 control pairs were identified between 1998 and 2008 from the Taiwan Longitudinal Health Insurance Database. Maternal APAP exposure during pregnancy was assessed.

RESULTS

After adjustment for potential confounders, there was a significant association between risk of offspring AD and exposure to acetaminophen in the first trimester (OR 1.16; 95% CI 1.05-1.28), the second trimester (OR 1.14; 95% CI 1.03-1.27), both first and second trimesters (OR 1.30; 95% CI 1.13-1.51), both first and third trimester (OR 1.20; 95% CI 1.04-1.39), any trimester (OR 1.12; 95% CI 1.00-1.26), and all three trimesters (OR 1.32; 95% CI 1.08-1.62) in a dose-response manner.

CONCLUSIONS

Prenatal exposure to acetaminophen was associated with an increased incidence of offspring AD.

摘要

背景

对乙酰氨基酚（APAP）已被认为与特应性疾病的发生有关。然而，关于产前 APAP 暴露与后代特应性皮炎（AD）之间的关系知之甚少。

目的

调查产前 APAP 暴露与后代 AD 风险之间的关系。

方法

本研究于 1998 年至 2008 年从台湾纵向健康保险数据库中确定了 2029 对研究对子（AD 患儿及其母亲）和 5058 对对照对子。评估了母亲在怀孕期间对 APAP 的暴露情况。

结果

在调整了潜在混杂因素后，与后代 AD 风险相关的是，在孕早期（OR 1.16；95%CI 1.05-1.28）、孕中期（OR 1.14；95%CI 1.03-1.27）、第一和第二孕期（OR 1.30；95%CI 1.13-1.51）、第一和第三孕期（OR 1.20；95%CI 1.04-1.39）、任何孕期（OR 1.12；95%CI 1.00-1.26）和所有三个孕期（OR 1.32；95%CI 1.08-1.62）中，APAP 暴露均呈剂量-反应关系。