Morgan D L, Peck S D
Department of Pathology, Presbyterian Denver Hospital, Colorado.
Am J Clin Pathol. 1988 Apr;89(4):513-5. doi: 10.1093/ajcp/89.4.513.
Forty patients on maintenance hemodialysis were studied to determine the usefulness of the red blood cell distribution width (RDW) in screening these patients for iron deficiency. Serum ferritin was used as the indicator of body iron stores. The sensitivity of RDW elevation in determining the likelihood of iron store depletion was 89%; and the negative predictive value of a normal RDW was 93%. The specificity of RDW elevation for iron deficiency was only 45%, and the positive predictive value was 32%. This study has confirmed the usefulness of the RDW as a screening test for iron deficiency in chronic hemodialysis patients. However, the low specificity and positive predictive value of the test also suggests the need for further studies when there is an unexplained elevation of the RDW.
对40例维持性血液透析患者进行了研究，以确定红细胞分布宽度（RDW）在筛查这些患者缺铁情况时的有用性。血清铁蛋白被用作机体铁储备的指标。RDW升高在确定铁储备耗竭可能性方面的敏感性为89%；RDW正常的阴性预测值为93%。RDW升高对缺铁的特异性仅为45%，阳性预测值为32%。本研究证实了RDW作为慢性血液透析患者缺铁筛查试验的有用性。然而，该试验较低的特异性和阳性预测值也表明，当RDW出现无法解释的升高时，需要进一步研究。
