Günay Süleyman, Paköz Betül, Çekiç Cem, Çamyar Hakan, Alper Emrah, Yüksel Elif Saritaş, Topal Firdevs, Binicier Ömer Burcak
Department of Gastroenterology, Katip Çelebi University, Atatürk Training and Research Hospital, Izmir.
Department of Gastroenterology, Koc Universitesi, Istanbul.
Medicine (Baltimore). 2021 Jan 22;100(3):e23175. doi: 10.1097/MD.0000000000023175.
Hydrogen peroxide is a liquid that functions in mechanical removal of the necrotic tissue via the elimination of tissue debris.In this study, we aimed to evaluate the effectiveness of the use of hydrogen peroxide in necrosectomy treatment of walled-off pancreatic necrosis.Records of 24 patients who were diagnosed with pancreatic necrosis or walled-off pancreatic necrosis and underwent endoscopic necrosectomy (EN) were retrospectively assessed. Patients were divided into 2 groups; hydrogen peroxide used for treatment or not used, and these 2 groups were compared.A total of 24 patients underwent endoscopic intervention for walled-off pancreatic necrosis. Procedural success was comparable between the 2 groups. During the post-procedural follow-up, the duration of the hospital stay, recurrence, and complication rates were found to be similar in both groups. The mean number of the endoscopic interventions was significantly lower in the hydrogen peroxide group (4.2 ± 1.4 vs 6.1 ± 4.2; P = .01).The use of hydrogen peroxide for EN in walled-off pancreatic necrosis patients seems to have similar efficiency and safety. However, it can be said that the use of hydrogen peroxide could reduce the number of endoscopic procedures.
过氧化氢是一种液体，通过清除组织碎片在机械性清除坏死组织方面发挥作用。在本研究中，我们旨在评估使用过氧化氢进行内镜下坏死组织清除术治疗包裹性胰腺坏死的有效性。对24例被诊断为胰腺坏死或包裹性胰腺坏死并接受内镜下坏死组织清除术（EN）的患者记录进行回顾性评估。患者分为两组；一组使用过氧化氢治疗，另一组未使用，对这两组进行比较。共有24例患者接受了内镜下包裹性胰腺坏死干预治疗。两组的手术成功率相当。在术后随访期间，发现两组的住院时间、复发率和并发症发生率相似。过氧化氢组的内镜干预平均次数显著更低（4.2±1.4 vs 6.1±4.2；P = 0.01）。在包裹性胰腺坏死患者中使用过氧化氢进行内镜下坏死组织清除术似乎具有相似的效率和安全性。然而，可以说使用过氧化氢可以减少内镜操作的次数。
