Cao Xihuang, Xue Jiaming, Yang Huiliang, Han Xiao, Zu Guo
Department of Emergency Surgery, The Dalian Municipal Central Hospital, China.
Department of General Surgery, The Dalian Municipal Central Hospital, China.
J Coll Physicians Surg Pak. 2021 Jan;31(1):83-88. doi: 10.29271/jcpsp.2021.01.83.
This study explored the relationship between the pretreatment systemic immune-inflammation index (SII) and overall survival (OS) in gastric cancer (GC) patients. A systemic literature search was performed to find out the articles that estimated the relationship of SII with specific clinical parameters and OS in GC patients. Nine articles (including 10 studies) were included. A total of 3,850 cases were eventually included. In GC patients, there was no association between pretreatment SII and gender (OR=0.991, p=0.944) or differentiation (OR=1.093, p=0.687). However, pretreatment SII was related to depth of tumor invasion (OR=0.340, p <0.001), lymph node metastasis (OR=0.447, p <0.001) and TNM stage (OR=0.361, p <0.001) in GC patients. The ORs of 1-year, 3-year and 5-year OS were 0.467 (I2=0.0%; p=0.682), 0.355 (I2=85.6%; p <0.001) and 0.507 (I2=56.4%; p=0.057). The pretreatment SII could be used as an indicator of the depth of tumor invasion, lymph node metastasis, TNM stage and overall of gastric cancer patients. However, more multi-centres researches are needed to confirm these findings. Key Words: Systemic immune-inflammation index (SII), Prognosis, Gastric cancer.
本研究探讨了胃癌（GC）患者治疗前全身免疫炎症指数（SII）与总生存期（OS）之间的关系。进行了一项系统的文献检索，以找出评估SII与GC患者特定临床参数及OS之间关系的文章。纳入了9篇文章（包括10项研究）。最终共纳入3850例病例。在GC患者中，治疗前SII与性别（OR = 0.991，p = 0.944）或分化程度（OR = 1.093，p = 0.687）之间无关联。然而，治疗前SII与GC患者的肿瘤浸润深度（OR = 0.340，p <0.001）、淋巴结转移（OR = 0.447，p <0.001）及TNM分期（OR = 0.361，p <0.001）相关。1年、3年和5年OS的OR分别为0.467（I2 = 0.0%；p = 0.682）、0.355（I2 = 85.6%；p <0.001）和0.507（I2 = 56.4%；p = 0.057）。治疗前SII可作为GC患者肿瘤浸润深度、淋巴结转移、TNM分期及总体情况的指标。然而，需要更多的多中心研究来证实这些发现。关键词：全身免疫炎症指数（SII）、预后、胃癌
