脑桥小细胞室旁核催产素神经元与自闭症谱系障碍
Parvocellular Oxytocin Neurons and Autism Spectrum Disorders.
机构信息
University of Luebeck, Institute for Experimental and Clinical Pharmacology and Toxicology, Ratzeburger Allee 160, 23562 Luebeck, Germany.
出版信息
Trends Endocrinol Metab. 2021 Apr;32(4):195-197. doi: 10.1016/j.tem.2021.01.004. Epub 2021 Feb 2.
PMID:33546964
Abstract
The underlying mechanism of oxytocin (OT) neurons in the development of social interaction remains unclear. In a recent study, Lewis et al. characterized OT neuronal subtypes and provided evidence that expression of the autism spectrum disorder (ASD) gene Fmr1 in parvocellular OT neurons is essential for peer-peer but not filial social interactions.
摘要
催产素（OT）神经元在社会互动发展中的潜在机制尚不清楚。在最近的一项研究中，Lewis 等人对 OT 神经元亚型进行了特征描述，并提供了证据表明自闭症谱系障碍（ASD）基因 Fmr1 在小细胞 OT 神经元中的表达对于同伴间而非亲子间的社会互动是必需的。
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