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IRGM1，线粒体 DAMPs 介导的自身炎症的守护者。

IRGM1, a guardian of mitochondrial DAMP-mediated autoinflammation.

机构信息

Center for Metabolism and Mitochondrial Medicine, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Aging Institute, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

出版信息

Nat Immunol. 2021 Mar;22(3):272-273. doi: 10.1038/s41590-021-00877-6.

DOI:10.1038/s41590-021-00877-6
PMID:33547457
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8607984/
Abstract

IRGM1 is recognized as a master regulator of type I interferon responses against pathogens, while also protecting against autoimmune diseases. It has now been shown that IRGM1 controls autoinflammatory responses by modulating mitophagy flux.

摘要

IRGM1 被认为是针对病原体的 I 型干扰素反应的主调控因子，同时也能预防自身免疫性疾病。现在已经表明，IRGM1 通过调节线粒体自噬通量来控制自身炎症反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba30/8607984/44760700b296/nihms-1755376-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba30/8607984/44760700b296/nihms-1755376-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba30/8607984/44760700b296/nihms-1755376-f0001.jpg

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本文引用的文献

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Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.自身免疫基因 IRGM 抑制 cGAS-STING 和 RIG-I-MAVS 信号转导以控制干扰素反应。
EMBO Rep. 2020 Sep 3;21(9):e50051. doi: 10.15252/embr.202050051. Epub 2020 Jul 27.
2
Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.Irgm1 缺陷导致结肠固有层髓系功能障碍，并易患肠道病原体柠檬酸杆菌。
PLoS Pathog. 2020 May 26;16(5):e1008553. doi: 10.1371/journal.ppat.1008553. eCollection 2020 May.
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Mitochondrial DNA in inflammation and immunity.
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Metabolic alterations of the immune system in the pathogenesis of autoimmune diseases.免疫系统代谢改变在自身免疫性疾病发病机制中的作用。
PLoS Biol. 2023 Apr 25;21(4):e3002084. doi: 10.1371/journal.pbio.3002084. eCollection 2023 Apr.
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Advances on the early cellular events occurring upon exposure of human macrophages to aluminum oxyhydroxide adjuvant.人巨噬细胞暴露于铝氧水凝胶佐剂后早期细胞事件的研究进展。
Sci Rep. 2023 Feb 23;13(1):3198. doi: 10.1038/s41598-023-30336-1.
线粒体 DNA 与炎症和免疫。
EMBO Rep. 2020 Apr 3;21(4):e49799. doi: 10.15252/embr.201949799. Epub 2020 Mar 23.
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The sensing of mitochondrial DAMPs by non-immune cells.非免疫细胞对线粒体损伤相关分子模式的感知。
Cell Stress. 2019 May 23;3(6):195-207. doi: 10.15698/cst2019.06.190.
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J Leukoc Biol. 2018 Feb;103(2):233-257. doi: 10.1189/jlb.3MR0617-250R. Epub 2017 Dec 29.
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