用小分子抑制剂破坏EGR-1的DNA结合可改善2,4-二硝基氯苯诱导的皮肤炎症。 - Suppr

Disrupting the DNA Binding of EGR-1 with a Small-Molecule Inhibitor Ameliorates 2,4-Dinitrochlorobenzene-Induced Skin Inflammation.

作者信息

Yeo Hyunjin, Ahn Sung Shin, Lee Jeong Yeon, Jung Euitaek, Jeong Munki, Kang Gi Sue, Ahn Seunghyun, Lee Youngshim, Koh Dongsoo, Lee Young Han, Lim Yoongho, Shin Soon Young

机构信息

Department of Biological Sciences, Sanghuh College of Life Sciences, Konkuk University, Seoul, Republic of Korea.

Department of Applied Chemistry, Dongduk Women's University, Seoul, Republic of Korea.

出版信息

J Invest Dermatol. 2021 Jul;141(7):1851-1855. doi: 10.1016/j.jid.2020.12.029. Epub 2021 Feb 4.

DOI:10.1016/j.jid.2020.12.029

PMID:33548243

Abstract

摘要

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Disrupting the DNA Binding of EGR-1 with a Small-Molecule Inhibitor Ameliorates 2,4-Dinitrochlorobenzene-Induced Skin Inflammation.用小分子抑制剂破坏EGR-1的DNA结合可改善2,4-二硝基氯苯诱导的皮肤炎症。

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Design, synthesis, and biological evaluation of 2-(2-oxoindolin-3-ylidene)hydrazinecarbothioamides as a potential EGR-1 inhibitor for targeted therapy of atopic dermatitis.设计、合成和生物评价 2-(2-氧代吲哚啉-3-亚基)肼甲硫酰胺作为一种潜在的 EGR-1 抑制剂，用于特应性皮炎的靶向治疗。

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The prevention of 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo.爪果木对 BALB/c 小鼠特应性皮炎样皮损中 2,4-二硝基氯苯诱导的炎症的预防作用。

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Disrupting the DNA Binding of EGR-1 with a Small-Molecule Inhibitor Ameliorates 2,4-Dinitrochlorobenzene-Induced Skin Inflammation.

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