Private Practitioner, Arzano, NA, Italy; Clinica Veterinaria Malpensa, Samarate, VA, Italy.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Top Companion Anim Med. 2021 Jun;43:100528. doi: 10.1016/j.tcam.2021.100528. Epub 2021 Feb 4.
Sarcoptes scabiei var. cuniculi are cutaneous mites of companion rabbits. In rabbits, sarcoptic mange is characterized by intense pruritus, alopecia, erythema, scales, and crusts around the head, neck, trunk, feet, and genitals. The goal of this study was to evaluate the effectiveness of oral fluralaner in pet rabbits naturally infested by S scabiei var. cuniculi. Twelve privately owned pet rabbits with a definitive diagnosis of sarcoptic mange were included in the study if they had compatible clinical signs and positive superficial skin scrapings for S scabiei. Clinical and parasitological evaluations were performed on days 0, 7, 14, 21, 30, 60, and 90 after receiving a single oral dose of 25 mg/kg of fluralaner. On day 7, 5 of 12 rabbits had positive skin scrapings, while 8 of 12 had clinical signs (alopecia and erythema) still present. By day 14 none of the rabbits had positive skin scrapings and only 1 of 12 had persistent clinical signs. By day 21 none of the rabbit had positive skin scrapings nor had clinical signs. A reoccurrence of the clinical signs or positive skin scrapings was not observed for the duration of the study (day 90). A single oral dose of fluralaner was effective for the treatment of naturally occurring sarcoptic mange in rabbits over a 90-day period.
兔疥螨是家兔的皮肤螨。在兔子中，疥螨病的特征是剧烈瘙痒、脱毛、红斑、鳞片和头部、颈部、躯干、脚部和生殖器周围的结痂。本研究的目的是评估口服氟雷拉纳在被兔疥螨自然感染的宠物兔中的疗效。如果具有明确的临床症状和兔疥螨的阳性皮肤刮片，则将 12 只私人拥有的宠物兔纳入研究中。在接受 25mg/kg 的氟雷拉纳单剂量口服后，在第 0、7、14、21、30、60 和 90 天进行临床和寄生虫学评估。第 7 天，12 只兔子中有 5 只有阳性皮肤刮片，而 12 只兔子中有 8 只有临床症状（脱毛和红斑）仍存在。第 14 天，没有兔子有阳性皮肤刮片，只有 12 只中的 1 只有持续的临床症状。第 21 天，没有兔子有阳性皮肤刮片，也没有临床症状。在研究期间（第 90 天），未观察到临床症状或阳性皮肤刮片再次出现。单剂量口服氟雷拉纳在 90 天内有效治疗兔子自然发生的疥螨病。
