GAPVD1 基因多态性、表达水平与多发性硬化症患者对干扰素-β反应的相关性。
An interdependence between GAPVD1 gene polymorphism, expression level and response to interferon beta in patients with multiple sclerosis.
机构信息
Immunology research center, Tabriz University of medical science, Tabriz, Iran; Department of Medical Genetics, Faculty of Medicine, Tabriz university of Medical Sciences, Tabriz, Iran.
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Neuroimmunol. 2021 Apr 15;353:577507. doi: 10.1016/j.jneuroim.2021.577507. Epub 2021 Jan 30.
Interferon-β (IFN-β) is among the first drugs used for reducing the symptoms of multiple sclerosis (MS). Many studies show that the genetic predisposition of patients might modulate their response to IFN-β treatment. In this study GAPVD1 gene expression and the genotyping of rs2291858 variant were analysed in 100 responder and 100 non-responder patients with MS treated using IFN-β. Moreover, rs2291858 genotyping was performed for 200 patients with MS and 200 healthy controls. GAPVD1 expression was significantly increased in the responder patients than in non-responders and the distribution of rs2291858 polymorphism was significantly different between them. The GAPVD1 expression level in AA genotype of the responder group was higher than that in other genotypes of these two groups. The results show that the GAPVD1 expression level and rs2291858 genotype probably affect the response to IFN- β in patients with MS.
干扰素-β（IFN-β）是用于减轻多发性硬化症（MS）症状的首批药物之一。许多研究表明，患者的遗传易感性可能会调节他们对 IFN-β治疗的反应。在这项研究中，分析了 100 名使用 IFN-β治疗的 MS 应答者和 100 名无应答者患者的 GAPVD1 基因表达和 rs2291858 变异型的基因分型。此外，对 200 名 MS 患者和 200 名健康对照者进行了 rs2291858 基因分型。应答者患者的 GAPVD1 表达水平明显高于无应答者，并且它们之间 rs2291858 多态性的分布明显不同。应答组 AA 基因型的 GAPVD1 表达水平高于这两组其他基因型的表达水平。结果表明，GAPVD1 表达水平和 rs2291858 基因型可能会影响 MS 患者对 IFN-β的反应。
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