O'Connor S A, Wilkinson D J
Department of Medical Electronics, St. Bartholomew's Hospital, West Smithfield, London, United Kingdom.
Anesth Analg. 1988 Apr;67(4):324-8.
Nalbuphine hydrochloride 0.2 mg/kg was compared with meperidine 0.5 mg/kg in a double-blind study in 20 patients undergoing elective inguinal hernia repair while breathing spontaneously under general anesthesia. The respiratory effects of the two drugs studied were continuously and accurately recorded with a wet wedge spirometer throughout the procedure. The acute respiratory effects of these analgesic drugs could therefore be assessed. The measurements recorded before any surgical stimulation showed that both nalbuphine and meperidine produce a similar degree of respiratory depression. These results are at variance with earlier studies that drew conclusions from measurements that were neither continuous nor accurate. Nalbuphine was found to be a satisfactory analgesic adjuvant in this anesthetic technique.
在一项双盲研究中，对20例在全身麻醉下自主呼吸接受择期腹股沟疝修补术的患者，比较了盐酸纳布啡0.2毫克/千克与哌替啶0.5毫克/千克的效果。在整个手术过程中，使用湿式楔型肺活量计持续准确记录两种药物的呼吸效应。因此可以评估这些镇痛药的急性呼吸效应。在任何手术刺激前记录的测量结果表明，纳布啡和哌替啶产生的呼吸抑制程度相似。这些结果与早期研究不同，早期研究是基于既不连续也不准确的测量得出结论的。在这种麻醉技术中，纳布啡被发现是一种令人满意的镇痛辅助药物。
