Department of Neurology, the Second Hospital of Dalian Medical University, Dalian City, Liaoning Province, China.
Development planning and Quality management Department, the Second Hospital of Dalian Medical University, Dalian City, Liaoning Province, China.
Clin Neurol Neurosurg. 2021 Mar;202:106516. doi: 10.1016/j.clineuro.2021.106516. Epub 2021 Jan 27.
Cerebral venous thrombosis (CVT) has various clinical presentations and has a median onset delay of 7 days. So it is important to find more identifiable early imaging manifestations for CVT.
This was a retrospective study. Patients with CVT (CVT group, n = 26) diagnosed by conventional imaging techniques (magnetic resonance imaging and/or digital subtraction angiogram) and patients with symptomatic intracranial atherosclerosis (control group, n = 30) were included. Magnetic resonance black-blood thrombus imaging (MRBTI) technique had been performed in both groups. The CVT group was divided into 3 groups based on the duration of clinical onset: ≤7 days (group 1), between 7 and 30 days (group 2), and >30 days (group 3). Pathological pachymeningeal enhancement and its characteristics were analyzed between the CVT group and the control group.
Pathological pachymeningeal enhancement was found in 14 CVT patients (54 %) and none in control group (P value = 0.000). The bilateral pathological pachymeningeal enhancement was involved in 10 CVT patients, 6 patients were asymmetric, and 4 patients had ipsilateral enhancement. Asymmetric pathological pachymeningeal enhancement was 71 % and predominantly located on the thrombosed sinus side. Strong enhancement was found in the venous sinus wall beside the thrombus. Pathological pachymeningeal enhancement percentages of three subgroups were 75 % in group 1, 55 % in group 2, and 29 % in group 3 and had no statistical differences (p value = 0.198).
Current findings suggest asymmetrical pathological pachymeningeal enhancement was associated was CVT and may be a new imaging feature for CVT.
脑静脉血栓形成（CVT）有多种临床表现，平均发病延迟为 7 天。因此，寻找更具特征性的早期 CVT 影像学表现非常重要。
这是一项回顾性研究。纳入经常规影像学技术（磁共振成像和/或数字减影血管造影）诊断为 CVT 的患者（CVT 组，n=26）和有症状颅内动脉粥样硬化患者（对照组，n=30）。两组均行磁共振黑血血栓成像（MRBTI）技术。根据临床发病时间将 CVT 组分为 3 组：≤7 天（组 1）、7-30 天（组 2）和>30 天（组 3）。分析 CVT 组和对照组之间病理性硬脑膜强化及其特征。
14 例 CVT 患者（54%）发现病理性硬脑膜强化，对照组无一例（P 值=0.000）。10 例 CVT 患者双侧病理性硬脑膜强化，6 例不对称，4 例同侧强化。不对称病理性硬脑膜强化占 71%，主要位于血栓形成的静脉窦侧。血栓旁静脉窦壁有明显强化。三组亚组的病理性硬脑膜强化百分比分别为组 1 中 75%，组 2 中 55%，组 3 中 29%，差异无统计学意义（p 值=0.198）。
目前的研究结果表明，不对称性病理性硬脑膜强化与 CVT 有关，可能是 CVT 的一种新的影像学特征。
