Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China.
BMC Cancer. 2021 Feb 6;21(1):131. doi: 10.1186/s12885-021-07859-9.
The associations between fasting blood glucose and staging and overall survival of patients with pancreatic cancer are still controversial. This study aimed to investigate the association between fasting blood glucose levels and overall survival (OS) of patients with pancreatic cancer and to evaluate the impact of differentiation and staging of pancreatic cancer.
This was a retrospective study of patients with pathologically confirmed pancreatic cancer admitted to Shengjing Hospital of China Medical University between 01/2012 and 12/2016. The outcome was the OS. The factors associated with OS were examined using univariable and multivariable Cox and logistic regression analyses.
A total of 253 patients were included. Preoperative blood glucose levels were not significantly associated with the OS of patients with pancreatic cancer (HR = 1.04, 95%CI: 0.78-1.40, P = 0.781). Only CA199 > 1000 was independently associated with OS (HR = 1.86, 95%CI: 1.15-3.02, P = 0.012). The median survival in the normal glucose group was 20.5 months (95% confidence interval (CI): 14.2-26.9). The median survival in the high glucose group was 14.2 months (95% CI: 9.7-18.6). There was no statistically significant difference between the two groups (P = 0.573). Multivariable logistic regression analyses were performed to determine if blood glucose levels influenced the 1- and 2-year OS. No significant association was observed for 1-year (OR = 1.27, 95%CI: 0.71-2.29, P = 0.418) or 2-year (HR = 1.37, 95%CI: 0.76-2.46, P = 0.296) OS.
Fasting blood glucose levels are not associated with the OS of patients with pancreatic adenocarcinoma.
空腹血糖与胰腺癌患者的分期和总生存的相关性仍存在争议。本研究旨在探讨空腹血糖水平与胰腺癌患者总生存（OS）的关系，并评估其对胰腺癌分化和分期的影响。
这是一项回顾性研究，纳入了 2012 年 1 月至 2016 年 12 月在中国医科大学盛京医院经病理证实的胰腺癌患者。结局为 OS。采用单变量和多变量 Cox 及 logistic 回归分析探讨与 OS 相关的因素。
共纳入 253 例患者。术前血糖水平与胰腺癌患者的 OS 无显著相关性（HR=1.04，95%CI：0.78-1.40，P=0.781）。只有 CA199>1000 与 OS 独立相关（HR=1.86，95%CI：1.15-3.02，P=0.012）。正常血糖组的中位生存时间为 20.5 个月（95%置信区间（CI）：14.2-26.9）。高血糖组的中位生存时间为 14.2 个月（95%CI：9.7-18.6）。两组间差异无统计学意义（P=0.573）。进一步行多变量 logistic 回归分析，以确定血糖水平是否影响 1 年和 2 年 OS。1 年（OR=1.27，95%CI：0.71-2.29，P=0.418）和 2 年（HR=1.37，95%CI：0.76-2.46，P=0.296）OS 均无显著相关性。
空腹血糖水平与胰腺腺癌患者的 OS 无相关性。
