Morris K G, Phillips H R
Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Angiology. 1988 Mar;39(3 Pt 2):321-6.
The hemodynamic effects of intravenous pirmenol were studied in 21 subjects instrumented with peripheral arterial, pulmonary artery, and left ventricular catheters. Baseline measurements of heart rate, cardiac output, pulmonary artery pressure, systemic arterial pressure, left ventricular end-diastolic pressure, left ventricular stroke work, and ejection fraction were obtained. An infusion of pirmenol hydrochloride was administered and hemodynamic measurements were repeated an average of 16.1 minutes following the start of the infusion after a new stable hemodynamic state was achieved. Significant increases in heart rate and systemic arterial pressure were noted. There were no significant changes in cardiac output, pulmonary arterial pressure, or left ventricular end-diastolic pressure. Significant reductions in left ventricular stroke work and ejection fraction were demonstrated. The amount of decrease in the ejection fraction was not related to the plasma pirmenol level achieved or to the baseline level of ventricular function. These findings suggest a negative inotropic effect of acute infusions of pirmenol and suggest caution should be used in its administration to patients with compromised left ventricular performance.
对21名安装了外周动脉、肺动脉和左心室导管的受试者研究了静脉注射吡美诺的血流动力学效应。获得了心率、心输出量、肺动脉压、体动脉压、左心室舒张末期压力、左心室每搏功和射血分数的基线测量值。给予盐酸吡美诺输注，在达到新的稳定血流动力学状态后，输注开始后平均16.1分钟重复进行血流动力学测量。观察到心率和体动脉压显著升高。心输出量、肺动脉压或左心室舒张末期压力无显著变化。左心室每搏功和射血分数显著降低。射血分数的降低量与达到的血浆吡美诺水平或心室功能的基线水平无关。这些发现提示急性输注吡美诺有负性肌力作用，并提示在将其给予左心室功能受损的患者时应谨慎使用。
