Servicio de Endocrinología y Nutrición, Instituto de Investigación Sanitaria y Biomédica de Alicante-Hospital General Universitario de Alicante, Universidad Miguel Hernández, Alicante, España.
Servicio de Anatomía Patológica, Hospital General Universitario de Alicante/ISABIAL, Alicante, España.
Endocrinol Diabetes Nutr (Engl Ed). 2021 Mar;68(3):196-207. doi: 10.1016/j.endinu.2020.10.004. Epub 2021 Feb 3.
Pituitary neuroendocrine tumors (PitNETs) constitute, together with other tumors of the sellar region, 15-25% of intracranial neoplasms. In 2017, the World Health Organization proposed a new classification of PitNETs. The main innovation with respect to the 2004 classification was the recommendation to include in the immunohistochemical evaluation of PitNETs the determination of the transcription factors of the 3 pituitary cell lineages: Pit-1, Tpit and SF-1. Additionally, other clinicopathological classifications with a predictive capacity of tumor behavior during follow-up were proposed. Given these changes, it is appropriate to adapt the knowledge generated during the last 15 years to the daily practice of the treatment and monitoring of PitNETs at the Centers of Excellence in Pituitary Pathology. This document includes the positioning of the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Society of Pathology (SEAP) on the classification and denomination of the PitNETs and the information that the pathologist should provide to the clinician to facilitate the treatment and monitoring of these tumors.
垂体神经内分泌肿瘤（PitNETs）与鞍区其他肿瘤一起占颅内肿瘤的 15-25%。2017 年，世界卫生组织提出了一种新的 PitNETs 分类。与 2004 年的分类相比，主要的创新之处在于建议在 PitNETs 的免疫组织化学评估中确定 3 种垂体细胞谱系的转录因子：Pit-1、Tpit 和 SF-1。此外，还提出了其他具有预测肿瘤在随访期间行为能力的临床病理分类。鉴于这些变化，有必要将过去 15 年产生的知识应用于在垂体病理卓越中心对 PitNETs 的治疗和监测的日常实践中。本文件包括内分泌学会（SEEN）和病理学学会（SEAP）在 PitNETs 的分类和命名方面的立场，以及病理学家应向临床医生提供的信息，以促进这些肿瘤的治疗和监测。
