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Exploratory Analyses for Missing Data in Meta-Analyses and Meta-Regression: A Tutorial.

作者信息

Schauer Jacob M, Diaz Karina, Pigott Therese D, Lee Jihyun

机构信息

Northwestern University, 680 N Lake Shore Dr, Ste 1400, Chicago, IL 60611, USA.

Columbia University, 116th and Broadway, New York, NY 10027, USA.

出版信息

Alcohol Alcohol. 2022 Jan 8;57(1):35-46. doi: 10.1093/alcalc/agaa144.

DOI:10.1093/alcalc/agaa144
PMID:33550367
Abstract

OBJECTIVES

In this tutorial, we examine methods for exploring missingness in a dataset in ways that can help to identify the sources and extent of missingness, as well as clarify gaps in evidence.

METHODS

Using raw data from a meta-analysis of substance abuse interventions, we demonstrate the use of exploratory missingness analysis (EMA) including techniques for numerical summaries and visual displays of missing data.

RESULTS

These techniques examine the patterns of missing covariates in meta-analysis data and the relationships among variables with missing data and observed variables including the effect size. The case study shows complex relationships among missingness and other potential covariates in meta-regression, highlighting gaps in the evidence base.

CONCLUSION

Meta-analysts could often benefit by employing some form of EMA as they encounter missing data.

摘要

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