Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
J Asian Nat Prod Res. 2022 Jan;24(1):66-75. doi: 10.1080/10286020.2021.1874941. Epub 2021 Feb 8.
Eighteen novel 3/5(3,5)-(di)nitropaeonol hydrazone derivatives were prepared, and their structures well characterized by H NMR, HRMS, and mp. Due to the steric hindrance, the substituents on the C = N double bond of all hydrazine compounds (except = 4/1 for , , , and = 3/2 for , ) adopted configuration. Among all compounds, four compounds , , , and exhibited potent nematicidal activity than their precursor paeonol, especially 5-nitropaeonol () and 3,5-dinitropaeonol () displayed the most potent nematicidal activity with LC values of 32.3307 and 36.7074 mg/L, respectively.
合成了 18 种新型 3/5(3,5)-(二)硝基丹皮酚腙衍生物，并通过 H NMR、HRMS 和 mp 对其结构进行了很好的表征。由于空间位阻的影响，所有腙化合物（除 5-硝基丹皮酚（ ）和 3,5-二硝基丹皮酚（ ）的 ＝ 4/1 和 ＝ 3/2 外）的 C ＝ N 双键上的取代基均采用 构型。在所有化合物中，四种化合物 、 、 和 表现出比其前体丹皮酚更强的杀线虫活性，特别是 5-硝基丹皮酚（ ）和 3,5-二硝基丹皮酚（ ）表现出最强的杀线虫活性，LC 值分别为 32.3307 和 36.7074 mg/L。
