Farland Leslie V, Harris Holly R
Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ.
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Curr Obstet Gynecol Rep. 2020 Sep;9(3):79-88. doi: 10.1007/s13669-020-00287-9. Epub 2020 May 29.
The purpose of this review is to discuss the most up to date research on endometriosis and chronic disease risk, highlighting the role treatments for endometriosis may play in these associations.
Previous studies have shown a consistent association between endometriosis and risk for epithelial ovarian cancer but the association with other cancers is less clear. Current research indicates that endometriosis may in be associated with risk of systemic lupus erythematosus, and potentially other autoimmune diseases. Limited evidence is also present for the association between endometriosis and cardiovascular disease and related conditions (e.g,. hypertension, hypercholesterolemia). A potential explanation for a portion of the increased risk of chronic diseases among women with endometriosis may relate to treatments for endometriosis impacting these outcomes.
Given the prevalence of endometriosis, understanding the relation between endometriosis and other chronic diseases has the potential to impact the health of many women. However, few high-quality studies with limited biases and adequate follow-up currently exist. Future multi-disciplinary research in prospective cohorts, with ample follow-up time, and detailed information on endometriosis characteristics and treatment is critical to advancing our understanding of this disease and its consequences.
本综述旨在讨论子宫内膜异位症与慢性病风险的最新研究，强调子宫内膜异位症治疗在这些关联中可能发挥的作用。
既往研究表明子宫内膜异位症与上皮性卵巢癌风险之间存在一致关联，但与其他癌症的关联尚不清楚。目前的研究表明，子宫内膜异位症可能与系统性红斑狼疮以及潜在的其他自身免疫性疾病风险相关。关于子宫内膜异位症与心血管疾病及相关病症（如高血压、高胆固醇血症）之间的关联也有有限的证据。子宫内膜异位症女性慢性病风险增加的部分潜在原因可能与子宫内膜异位症的治疗对这些结果产生影响有关。
鉴于子宫内膜异位症的患病率，了解子宫内膜异位症与其他慢性病之间的关系有可能影响众多女性的健康。然而，目前很少有高质量、偏差有限且随访充分的研究。未来在前瞻性队列中进行多学科研究，有足够的随访时间，并提供有关子宫内膜异位症特征和治疗的详细信息，对于增进我们对这种疾病及其后果的理解至关重要。
