一名长期接受良好控制的HIV感染患者发生隐球菌性脑膜脑炎的意外病例。
Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection.
作者信息
Yoon Hyun Ah, Riska Paul F, Jain Ruchika, Morales Cariane, Pirofski Liise-Anne
机构信息
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
出版信息
Med Mycol Case Rep. 2021 Jan 26;32:14-16. doi: 10.1016/j.mmcr.2021.01.003. eCollection 2021 Jun.
Abstract
Cryptococcal meningoencephalitis (CM) classically occurs in individuals with advanced HIV infection, solid organ transplants, or other immunocompromising conditions. We report a case of fatal CM in a 78-year-old woman with well-controlled HIV infection who had delayed diagnosis, persistently elevated intracranial pressure and pleocytosis of the cerebrospinal fluid. Initial suspicion for CM was low due to her relatively high CD4 T cell counts, which likely contributed to greater inflammation.
摘要
隐球菌性脑膜脑炎（CM）通常发生于晚期HIV感染、实体器官移植或其他免疫功能低下的个体。我们报告一例78岁女性的致命性CM病例，该患者HIV感染控制良好，但诊断延迟，颅内压持续升高，脑脊液出现细胞增多。由于她的CD4 T细胞计数相对较高，最初对CM的怀疑较低，这可能导致了更严重的炎症。
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