Morgant Stephanie, Artru Pascal, Oudjit Ammar, Lourenco Nelson, Pasquer Arnaud, Walter Thomas, Gornet Jean-Marc, Rouquette Alexandre, Brezault Catherine, Coriat Romain
Gastroenterology and digestive oncology unit, Hôpital Cochin, Paris, France.
Gastroenterology and Digestive Unit, Jean Mermoz Clinic, Lyon, France.
Ann Transl Med. 2021 Jan;9(1):50. doi: 10.21037/atm-20-3474.
Endoscopic ultrasound (EUS) is a key imaging technique in gastric cancer (GC). The aim of this study was to evaluate the performance of EUS in the staging of parietal and lymph node involvement in linitis plastica (LP) compared to "classical" GC.
A retrospective multicentric French study was conducted on patients with no metastatic LP and operated by gastrectomy. A 2/1 matching based on pTNM stage and center was performed with GC.
Forty-three patients were included, sixteen patients in the LP group and 27 in the control group. Sensitivity and specificity of EUS for diagnosis of T3-T4 parietal invasion were 77% and 100% respectively in the LP group and 89% and 56% respectively in the control group. Sensitivity and specificity of EUS for diagnosis of lymph node involvement were 73% and 80%, respectively in the LP group and 88% and 50%, respectively in the control group. Patients from LP group had significantly more advanced histological lesion, and frequent undiagnosed peritoneal carcinomatosis.
This study evaluated for the first time in a European population, the preoperative EUS performance in LP. Our study identified a similar sensitivity and specificity of the EUS in LP compared to "classical" GC paving for a broader use of EUS in preoperative settings.
内镜超声（EUS）是胃癌（GC）的一项关键成像技术。本研究的目的是评估与“经典”胃癌相比，EUS在皮革胃（LP）胃壁及淋巴结受累分期中的表现。
对无转移的LP患者且接受胃切除术的患者进行了一项回顾性多中心法国研究。基于pTNM分期和中心，将LP患者与胃癌患者进行2:1匹配。
共纳入43例患者，LP组16例，对照组27例。LP组EUS诊断T3 - T4胃壁侵犯的敏感性和特异性分别为77%和100%，对照组分别为89%和56%。LP组EUS诊断淋巴结受累的敏感性和特异性分别为73%和80%，对照组分别为88%和50%。LP组患者的组织学病变明显更晚期，且经常存在未被诊断出的腹膜癌转移。
本研究首次在欧洲人群中评估了LP患者术前EUS的表现。我们的研究发现，与“经典”胃癌相比，EUS在LP中的敏感性和特异性相似，这为EUS在术前环境中的更广泛应用奠定了基础。
