Zweig M H
Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.
Arch Pathol Lab Med. 1988 Apr;112(4):383-6.
Fundamental clinical performance of a laboratory test can be described in terms of accuracy, or the ability to correctly classify subjects into clinically relevant subgroups. Accuracy refers to the quality of the information provided by the classification device and should be distinguished from the efficacy, or practical usefulness, of the information. Receiver operating characteristic curves provide a pure index of accuracy by demonstrating the limits of a test's ability to discriminate between alternative states of health over the complete spectrum of operating conditions. If analytical imprecision is removed from the data, the resulting receiver operating characteristic curve represents the inherent biological variation that ultimately limits the clinical accuracy of the test.
实验室检测的基本临床性能可以用准确性来描述，即正确地将受试者分类到临床相关亚组的能力。准确性指的是分类设备所提供信息的质量，应与信息的有效性或实际有用性区分开来。通过展示在整个操作条件范围内测试区分健康状态的能力的极限，受试者工作特征曲线提供了一个纯粹的准确性指标。如果从数据中去除分析不精密度，得到的受试者工作特征曲线代表了最终限制检测临床准确性的内在生物学变异。
