Nutter P, Collins K
Seattle Veterans Administration Medical Center, WA 98108.
Arch Phys Med Rehabil. 1988 Apr;69(4):295-6.
Positive sharp waves occur in a variety of neurogenic, myogenic, and metabolic disorders. Although not synonymous with denervation, their presence is usually associated with some type of pathology. The authors found only one reported series of patients who had diffuse insertional positive waves but no demonstrable underlying disease. There were no follow-up reports and no other cases have been described. A patient is reported with diffuse insertional positive waves. He has been followed for over three years, remaining clinically normal. No electrolyte or metabolic abnormalities have been found. Two of the patient's four children showed normal results to limited EMG screening. This syndrome may represent an intrinsic defect in the muscle fiber cell membrane which makes it inherently unstable. It may also represent a form of myotonia; however, no evidence of that disease was found in this patient. This defect, which can only be detected by needle EMG, has so far not been associated with any neuromuscular deficit.
正锐波出现在多种神经源性、肌源性和代谢性疾病中。虽然它们与去神经支配并非同义，但它们的出现通常与某种类型的病理状况相关。作者仅发现一篇报道系列，其中患者有弥漫性插入性正波，但无明显的潜在疾病。没有随访报告，也未描述其他病例。本文报告一名有弥漫性插入性正波的患者。对其进行了三年多的随访，其临床情况一直正常。未发现电解质或代谢异常。该患者的四个孩子中有两个在有限的肌电图筛查中结果正常。这种综合征可能代表肌纤维细胞膜的一种内在缺陷，使其本质上不稳定。它也可能代表一种肌强直形式；然而，在该患者中未发现该疾病的证据。这种只能通过针电极肌电图检测到的缺陷，迄今为止尚未与任何神经肌肉功能障碍相关联。
