Chintapalli Renuka, Romero-Ortuno Roman
Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom.
Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Ireland.
EClinicalMedicine. 2020 Dec 5;31:100676. doi: 10.1016/j.eclinm.2020.100676. eCollection 2021 Jan.
Cognitive and motor function in ageing are intertwined, but whether slower motor response time (MRT) to a cognitive stimulus could herald accelerated mobility decline is unknown. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined whether slower MRT may predict a greater than expected increase in Time Up and Go (TUG) after 4 years.
Participants aged 50 years or older were divided into two groups based on their mean MRT (< 250 ms versus ≥ 250 ms). A repeated measures ANOVA compared TUG trajectories between groups, controlling for baseline age, sex, height, education level, mini mental-state examination (MMSE) score, self-reported vision and hearing, medical conditions (cardiovascular, cerebrovascular disease, diabetes), and number of medications.
At Wave 1, 1982 (58.7%) had a mean MRT of < 250 ms, with a mean TUG of 8.1 s (SD 1.6); and 1397 (41.3%) had an MRT of ≥ 250 ms, with a TUG of 9.0 s (SD 2.2). At Wave 3, TUG increased to 8.8 s (SD 2.0) and 10.2 s (SD 3.9), respectively. The results of the adjusted repeated measures ANOVA suggested that there was a statistically significant interaction between MRT group and Wave ( = 0.023, η = 0.002).
TILDA participants in the slower MRT group seemed to have faster mobility decline, but this effect was statistically and clinically small.
TILDA is funded by Atlantic Philanthropies, the Irish Department of Health and Irish Life. Roman Romero-Ortuno is funded by Science Foundation Ireland (grant number 18/FRL/6188).
衰老过程中的认知和运动功能相互交织，但对认知刺激的运动反应时间（MRT）变慢是否预示着运动能力加速下降尚不清楚。利用爱尔兰纵向老龄化研究（TILDA）的数据，我们研究了较慢的MRT是否可预测4年后起立行走测试（TUG）的增加幅度超过预期。
50岁及以上的参与者根据其平均MRT（<250毫秒与≥250毫秒）分为两组。采用重复测量方差分析比较两组之间的TUG轨迹，并控制基线年龄、性别、身高、教育水平、简易精神状态检查表（MMSE）评分、自我报告的视力和听力、医疗状况（心血管疾病、脑血管疾病、糖尿病）以及药物数量。
在第1波时，1982名（58.7%）参与者的平均MRT<250毫秒，平均TUG为8.1秒（标准差1.6）；1397名（41.3%）参与者的MRT≥250毫秒，TUG为9.0秒（标准差2.2）。在第3波时，TUG分别增加到8.8秒（标准差2.0）和10.2秒（标准差3.9）。调整后的重复测量方差分析结果表明，MRT组与波次之间存在统计学上的显著交互作用（P = 0.023，η² = 0.002）。
TILDA研究中MRT较慢组的参与者似乎运动能力下降更快，但这种影响在统计学和临床上都较小。
TILDA由大西洋慈善基金会、爱尔兰卫生部和爱尔兰人寿保险公司资助。罗曼·罗梅罗 - 奥图诺由爱尔兰科学基金会资助（资助编号18/FRL/6188）。
