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基于聚类分析的微创腰椎减压术后残留症状的分类和预后因素:一项 5 年随访队列研究。

Classification and prognostic factors of residual symptoms after minimally invasive lumbar decompression surgery using a cluster analysis: a 5-year follow-up cohort study.

机构信息

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan.

Department of Orthopaedic Surgery, Fuchu Hospital, Osaka, Japan.

出版信息

Eur Spine J. 2021 Apr;30(4):918-927. doi: 10.1007/s00586-021-06754-y. Epub 2021 Feb 8.

Abstract

PURPOSE

Residual symptoms indicating incomplete remission of lower leg numbness or low back pain may occur after spine surgery. The purpose was to elucidate the pattern of residual symptoms 5 years after minimally invasive lumbar decompression surgery using a cluster analysis.

METHODS

The study comprised 193 patients with lumbar spinal stenosis (LSS) (108 men, 85 women) ranging in age from 40 to 86 years (mean, 67.9 years). Each patient underwent 5-year follow-up. The Japanese Orthopedic Association score and visual analog scale scores for low back pain, leg pain, and leg numbness at 5 years were entered into the cluster analysis to characterize postoperative residual symptoms. Other clinical data were analyzed to detect the factors significantly related to each cluster.

RESULTS

The analysis yielded four clusters representing different patterns of residual symptoms. Patients in cluster 1 (57.0%) were substantially improved and had few residual symptoms of LSS. Patients in cluster 2 (11.4%) were poorly improved and had major residual symptoms. Patients in cluster 3 (17.6%) were greatly improved but had mild residual low back pain. Patients in cluster 4 (14.0%) were improved but had severe residual leg numbness. Prognostic factors of cluster 2 were a short maximum walking distance, motor weakness, resting lower leg numbness, cofounding scoliosis, and high sagittal vertical axis.

CONCLUSIONS

This is the first study to identify specific patterns of residual symptoms of LSS after decompression surgery. Our results will contribute to acquisition of preoperative informed consent and identification of patients with the best chance of postoperative improvement.

摘要

目的

下肢麻木或腰痛未完全缓解的残留症状在脊柱手术后可能会出现。本研究目的是通过聚类分析阐明微创腰椎减压术后 5 年残留症状的模式。

方法

本研究纳入了 193 例腰椎管狭窄症(LSS)患者(男 108 例,女 85 例),年龄 40~86 岁(平均 67.9 岁)。每位患者均进行了 5 年随访。将日本矫形协会评分和视觉模拟评分(VAS)中腰痛、腿痛和下肢麻木的 5 年随访结果纳入聚类分析,以明确术后残留症状。分析其他临床数据,以确定与每个聚类相关的因素。

结果

分析结果得出 4 个聚类,代表不同的残留症状模式。聚类 1(57.0%)的患者症状显著改善,残留 LSS 症状较少;聚类 2(11.4%)的患者改善不佳,残留症状较重;聚类 3(17.6%)的患者显著改善,但残留轻度腰痛;聚类 4(14.0%)的患者改善,但残留严重下肢麻木。聚类 2 的预后因素为最长步行距离短、运动无力、静息时下肢麻木、并存脊柱侧弯和矢状位垂直轴高。

结论

这是第一项关于减压手术后 LSS 残留症状特定模式的研究。本研究结果有助于获得术前知情同意,并识别术后改善可能性最大的患者。

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