Kritchevsky D, Tepper S A, Klurfeld D M
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Atherosclerosis. 1988 Jan;69(1):89-92. doi: 10.1016/0021-9150(88)90292-4.
Data relating to the effects of calcium channel blockers on experimental atherosclerosis in rabbits are inconsistent with most studies finding no effect on either serum lipids or atherosclerosis. We have administered flordipine (5, 15 or 45 mg/kg/day) for 10 weeks to rabbits fed 1% cholesterol and 4% corn oil. At no level of treatment was there an effect on serum or liver lipids or on aortic sudanophilia.
关于钙通道阻滞剂对兔实验性动脉粥样硬化影响的数据与大多数研究结果不一致，多数研究发现其对血清脂质或动脉粥样硬化均无影响。我们对喂食1%胆固醇和4%玉米油的兔给予氟桂利嗪（5、15或45毫克/千克/天），持续10周。在任何治疗水平下，对血清或肝脏脂质或主动脉苏丹嗜染均无影响。
