Weill Cornell Medicine, Department of Radiology, 525 East 68(th) Street, New York, NY 10065, United States of America.
Touro College of Osteopathic Medicine, 60 Prospect Avenue, Middletown, NY 10940, United States of America.
Clin Imaging. 2021 Aug;76:61-64. doi: 10.1016/j.clinimag.2021.01.032. Epub 2021 Feb 3.
Paraneoplastic limbic encephalitis (PLE) is an immunopathologic syndrome associated with malignancy and represents a rare remote outcome of tumor on the nervous system. We report a case of PLE caused by a regressed testicular germ cell tumor in an otherwise healthy young man, who presented with acute-onset confusion, memory impairment and anterograde amnesia. Prompt recognition of PLE is critical as it allows early treatment of both the primary tumor and PLE-related neurologic impairments, which can be severe and irreversible if treatment is delayed. Complete tumor treatment response offers the best chance for neurologic recovery in patients with PLE. To our knowledge, this is the second reported case of PLE with radiologic-pathologic correlation in the setting of a regressed testicular germ cell tumor.
副肿瘤性边缘系统脑炎（PLE）是一种与恶性肿瘤相关的免疫病理综合征，代表神经系统肿瘤的罕见远处后果。我们报告了一例由已消退的睾丸生殖细胞肿瘤引起的 PLE 病例，发生在一名原本健康的年轻男性身上，表现为急性发作的意识混乱、记忆障碍和顺行性遗忘。早期识别 PLE 至关重要，因为它可以早期治疗原发性肿瘤和 PLE 相关的神经功能障碍，如果治疗延迟，这些障碍可能会很严重且不可逆转。完全的肿瘤治疗反应为 PLE 患者的神经恢复提供了最佳机会。据我们所知，这是在已消退的睾丸生殖细胞肿瘤背景下具有放射病理学相关性的 PLE 的第二例报告病例。
