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抗Ro/SSA阳性妊娠中的家庭胎儿心率监测:文献综述与病例报告

Home fetal heart rate monitoring in anti Ro/SSA positive pregnancies: Literature review and case report.

作者信息

Milazzo Roberta, Ligato Elisa, Laoreti Arianna, Ferri Giulia, Basili Ludovica, Serati Lisa, Brucato Antonio, Cetin Irene

机构信息

Department of Woman, Mother and Neonate, "V. Buzzi" Children Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.

Department of Woman, Mother and Neonate, "V. Buzzi" Children Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2021 Apr;259:1-6. doi: 10.1016/j.ejogrb.2021.01.031. Epub 2021 Jan 28.

Abstract

Anti-Ro/SSA antibodies are associated with a risk of 1-2 % to develop complete atrioventricular block (AVB) in fetuses of positive mothers. Complete AVB is irreversible, but studies suggest that anti-inflammatory treatment during the transition period from a normal fetal heart rate (FHR) to an AVB might stop this progression and restore sinus rhythm. The most efficient method for diagnostic evaluation of this arrhythmia is the pulsed-Doppler fetal echocardiography. However, weekly or bi-weekly recommended fetal echocardiographic surveillance can rarely identify an AVB in time for treatment success, also because the transition from a normal rhythm to a third degree AVB is very fast. Daily FHR monitoring in a medical facility could increase the chances of identifying the AVB onset but is difficult to realize. For this reason, an alternative method of FHR monitoring, performed directly by mothers in their home context, has been recently proposed. We present a case report utilizing this approach and review the current evidence about this condition.

摘要

抗Ro/SSA抗体与母亲抗体呈阳性的胎儿发生完全性房室传导阻滞(AVB)的风险相关,发生率为1%-2%。完全性AVB是不可逆的,但研究表明,在胎儿心率(FHR)从正常转变为AVB的过渡期进行抗炎治疗,可能会阻止这种进展并恢复窦性心律。诊断这种心律失常最有效的方法是脉冲多普勒胎儿超声心动图。然而,每周或每两周进行一次胎儿超声心动图监测,很少能及时发现AVB以便治疗成功,这也是因为从正常心律转变为三度AVB非常迅速。在医疗机构进行每日FHR监测可能会增加识别AVB发作的机会,但难以实现。因此,最近有人提出一种由母亲直接在家中进行FHR监测的替代方法。我们报告一例采用这种方法的病例,并综述有关这种情况的现有证据。

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