Department of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Department of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Curr Opin Genet Dev. 2021 Apr;67:142-150. doi: 10.1016/j.gde.2021.01.005. Epub 2021 Feb 6.
The nuclear pore complex (NPC) is a massive nuclear envelope-embedded protein complex, the canonical function of which is to mediate selective nucleocytoplasmic transport. In addition to its transport function, the NPC has been shown to interact with the underlying chromatin and to influence both activating and repressive gene regulatory processes, contributing to the establishment and the epigenetic maintenance of cell identity. In this review, we discuss diverse gene regulatory functions of NPC components and emerging mechanisms underlying these functions, including roles in genome architecture, transcription complex assembly, chromatin remodeling, and coordination of transcription and mRNA export. These functional roles highlight the importance of the NPC as a nuclear scaffold directing genome organization and function.
核孔复合体（NPC）是一种巨大的核膜嵌入蛋白复合物，其典型功能是介导选择性核质转运。除了其转运功能外，NPC 已被证明与基底染色质相互作用，并影响激活和抑制基因调控过程，有助于细胞身份的建立和表观遗传维持。在这篇综述中，我们讨论了 NPC 成分的多种基因调控功能和这些功能的新兴机制，包括在基因组结构、转录复合物组装、染色质重塑以及转录和 mRNA 输出协调中的作用。这些功能作用强调了 NPC 作为核支架指导基因组组织和功能的重要性。
