冈比亚A组感染的分子流行病学
Molecular Epidemiology of Group A Infections in The Gambia.
作者信息
Jabang Sona, Erhart Annette, Darboe Saffiatou, Baldeh Aru-Kumba, Delforge Valerie, Watson Gabriella, Foster-Nyarko Ebenezer, Salaudeen Rasheed, Lawal Bolarinde, Mackenzie Grant, Botteaux Anne, Antonio Martin, Smeesters Pierre R
机构信息
Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The Gambia.
Laboratoire de Génétique et Physiologie Bactérienne, IBMM, Université Libre de Bruxelles, 12 Rue des Professeurs Jenner et Brachet, 6041 Gosselies, Belgium.
出版信息
Vaccines (Basel). 2021 Feb 4;9(2):124. doi: 10.3390/vaccines9020124.
Abstract
Molecular epidemiological data on Group A (GAS) infection in Africa is scarce. We characterized the types and -clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 and 2018. To reduce the potential for strain mistyping, we used a newly published primer for -typing. There was considerable strain diversity, highlighting the need for vaccine development offering broad strain protection.
摘要
非洲A组链球菌（GAS）感染的分子流行病学数据匮乏。我们对2004年至2018年间从冈比亚收集的433株储存临床GAS分离株的类型和簇进行了特征分析。为了降低菌株分型错误的可能性，我们使用了一种新发表的用于分型的引物。菌株存在相当大的多样性，这突出了开发具有广泛菌株保护作用的疫苗的必要性。
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