Machado M V, Crawford D C, Anderson R H, Allan L D
Department of Perinatal Cardiology, Guy's Hospital, London.
Br Heart J. 1988 Mar;59(3):352-5. doi: 10.1136/hrt.59.3.352.
In a series of more than 3500 pregnancies referred for fetal echocardiography, 29 cases of atrioventricular septal defect were detected in the fetus. There was a chromosomal anomaly in 14 of these cases, left atrial isomerism in 12, and right atrial isomerism in two. Complete heart block was found in 11 of the cases with left atrial isomerism. Many associated cardiac abnormalities were found, particularly in the fetuses with atrial isomerism; the most common were double outlet right ventricle or aortic arch anomalies. The prognosis was poor in all patients with atrioventricular septal defect detected prenatally. Fifteen pregnancies went to term but there are only four survivors. Two of those have trisomy 21, a further patient has inoperable defects, and only one remains well and is awaiting corrective surgery for a partial atrioventricular septal defect.
在一系列超过3500例因胎儿超声心动图检查而转诊的妊娠中，胎儿共检测出29例房室间隔缺损。其中14例存在染色体异常，12例为左心房异构，2例为右心房异构。在11例左心房异构病例中发现了完全性心脏传导阻滞。还发现了许多相关的心脏异常，特别是在心房异构的胎儿中；最常见的是右心室双出口或主动脉弓异常。所有产前检测出房室间隔缺损的患者预后都很差。15例妊娠足月，但只有4例存活。其中2例患有21三体综合征，另1例患者有无法手术治疗的缺陷，只有1例情况良好，正在等待对部分房室间隔缺损进行矫正手术。
