Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University, Shulan International Medical College, Hangzhou, Zhejiang, P.R. China.
Division of Oncology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.
J Int Med Res. 2021 Feb;49(2):300060520987771. doi: 10.1177/0300060520987771.
False positive and negative results are associated with biliary tract cell brushing cytology during endoscopic retrograde cholangiopancreatography (ERCP). The causes are uncertain. The purpose of this study was to evaluate the accuracy of diagnoses made via cell brushing in our center, and to explore the factors influencing diagnosis.
The clinical data of patients who underwent cell brushing at our center from January 2016 to August 2019 were retrospectively analyzed. These included age, gender, stricture location, thickness of the bile duct wall in the narrow segment, maximum diameter of the biliary duct above the stricture, number of cell brush smears, carbohydrate antigen 19-9, and carcinoembryonic antigen. Positive brush cytology results were compared with results of surgical histology or tumor biopsy as well as with the patient's clinical course.
Of the 48 patients who underwent cell brushing cytology, 27 (56.3%) had positive results. The sensitivity and specificity of biliary duct cell brushing was 79.4%, and 85.7%, respectively. None of the above-mentioned factors were associated with positive cytology brushing results.
Cell brushing cytology remains a reliable method for diagnosis of pancreaticobiliary malignancies.
经内镜逆行胰胆管造影术（ERCP）期间胆管细胞刷检的假阳性和假阴性结果与胆管细胞刷检有关。其原因尚不确定。本研究的目的是评估我们中心通过细胞刷检做出的诊断的准确性，并探讨影响诊断的因素。
回顾性分析了 2016 年 1 月至 2019 年 8 月在我院行细胞刷检的患者的临床资料，包括年龄、性别、狭窄部位、狭窄段胆管壁厚度、胆管上段最大直径、细胞刷涂片数、糖类抗原 19-9、癌胚抗原。阳性刷检结果与手术组织学或肿瘤活检结果以及患者的临床过程进行比较。
48 例行胆管细胞刷检的患者中，27 例（56.3%）结果阳性。胆管细胞刷检的灵敏度和特异性分别为 79.4%和 85.7%。上述因素均与细胞学刷检阳性结果无关。
细胞刷检仍然是诊断胰胆恶性肿瘤的可靠方法。
