Wang Jinghua, Liu Jinxiang, Pan Lu, Guo Lishuang, Liu Congcong, Yang Sirui
Department of Pediatric Rheumatology and Allergy, The First Hospital of Jilin University, Changchun, China.
Lupus. 2021 Apr;30(5):725-733. doi: 10.1177/0961203321991918. Epub 2021 Feb 8.
Previous studies have reported inconsistent results on the relationship between alcohol intake and the risk of systemic lupus erythematosus (SLE). Therefore, we conducted a systematic review and meta-analysis to illustrate the potential role of alcohol intake on the progression of SLE.
An electronic search of the PubMed, EmBase, and the Cochrane library databases was conducted from their inception up to March 2020. Observational studies that investigated the role of alcohol intake on the risk of SLE were eligible for inclusion in this study. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated as an effect estimate using the random-effects model.
Seven case-control studies (n = 3, 251) and three cohort studies (n = 322, 479) were selected for the final meta-analysis. Mild (OR: 0.85; 95% CI: 0.53-1.38; = 0.515) or heavy (OR: 0.63; 95% CI: 0.37-1.09; = 0.102) alcohol intake were not associated with the risk of SLE, while moderate alcohol intake could protect against the risk of SLE (OR: 0.71; 95% CI: 0.55-0.93; = 0.012). Sensitivity analysis suggested that heavy alcohol intake was associated with a reduced risk of SLE (OR: 0.47; 95% CI: 0.32-0.67; < 0.001).
This study found that moderate alcohol intake could protect against the risk of SLE, while mild or heavy alcohol intake did not significantly affect the risk of SLE.
既往研究报告了饮酒与系统性红斑狼疮（SLE）风险之间的关系，但结果并不一致。因此，我们进行了一项系统评价和荟萃分析，以阐明饮酒在SLE进展中的潜在作用。
对PubMed、EmBase和Cochrane图书馆数据库从建库至2020年3月进行电子检索。纳入调查饮酒对SLE风险作用的观察性研究。采用随机效应模型计算合并比值比（OR）及95%置信区间（CI）作为效应估计值。
最终荟萃分析纳入了7项病例对照研究（n = 3251）和3项队列研究（n = 322479）。轻度（OR：0.85；95%CI：0.53 - 1.38；P = 0.515）或重度（OR：0.63；95%CI：0.37 - 1.09；P = 0.102）饮酒与SLE风险无关，而中度饮酒可预防SLE风险（OR：0.71；95%CI：0.55 - 0.93；P = 0.）。敏感性分析表明，重度饮酒与SLE风险降低相关（OR：0.47；95%CI：0.32 - 0.67；P < 0.001）。
本研究发现，中度饮酒可预防SLE风险，而轻度或重度饮酒对SLE风险无显著影响。
