Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Otolaryngol Head Neck Surg. 2021 Sep;165(3):438-445. doi: 10.1177/0194599820987469. Epub 2021 Feb 9.
Although extranodal extension (ENE) is a known indicator of poor prognosis for head and neck malignancies, its value as an indicator for sinonasal squamous cell carcinoma (SCC) has not been well characterized. This study seeks to assess the usefulness of ENE as a prognostic marker for sinonasal SCC.
Retrospective database review.
National Cancer Database from 2010 to 2015.
The National Cancer Database was queried from 2010 to 2015 for all patients with sinonasal SCC with available ENE status (n = 355). These cases were divided into those with pathologically confirmed ENE (n = 146) and those without ENE (n = 209). Univariate and multivariate analyses were used to examine survival differences and predictors of ENE status.
Most patients with ENE were ≥60 years old (61.7%), male (61.6%), and white (83.6%). Patients aged 60 to 69 and 80+ years were more likely to have ENE than those under 60 years ( < .05). Patients with ENE had worse 1-year overall survival than those without ENE (58.2% vs 70.8%, log-rank = .008). After multivariate regression, however, there was no survival difference detected between ENE-positive and ENE-negative cases (hazard ratio, 1.14 [0.775-1.672], = .508).
ENE status did not have a significant effect on survival in patients with sinonasal SCC. Thus, ENE alone may not necessarily be a helpful indicator for sinonasal SCC prognosis.
虽然结外侵犯（ENE）是头颈部恶性肿瘤预后不良的已知指标，但它作为鼻窦鳞状细胞癌（SCC）的指标的价值尚未得到很好的描述。本研究旨在评估 ENE 作为鼻窦 SCC 预后标志物的有用性。
回顾性数据库研究。
2010 年至 2015 年国家癌症数据库。
从 2010 年至 2015 年，国家癌症数据库中查询了所有具有可用 ENE 状态的鼻窦 SCC 患者（n=355）。这些病例分为经病理证实有 ENE（n=146）和无 ENE（n=209）。使用单变量和多变量分析来检查生存差异和 ENE 状态的预测因素。
大多数有 ENE 的患者年龄≥60 岁（61.7%）、男性（61.6%）和白人（83.6%）。年龄在 60 至 69 岁和 80 岁以上的患者比 60 岁以下的患者更有可能出现 ENE（<0.05）。有 ENE 的患者 1 年总生存率比无 ENE 的患者差（58.2%比 70.8%，对数秩检验=0.008）。然而，经过多变量回归，ENE 阳性和 ENE 阴性病例之间的生存差异无统计学意义（风险比，1.14[0.775-1.672]，=0.508）。
ENE 状态对鼻窦 SCC 患者的生存无显著影响。因此，ENE 本身可能不一定是鼻窦 SCC 预后的有用指标。
