Mazzoni G, Benichou J, Porter K A, Starzl T E
Transplantation. 1977 Oct;24(4):268-73. doi: 10.1097/00007890-197710000-00006.
Kidneys were transplanted in mongrel dogs so that renal venous drainage was into the portal system of the hosts. Thirty-one recipients were not treated, 11 were given one dose of 3 mg of azathioprine per kg, and 11 were given 2 mg of azathioprine per day. Survival was not statistically increased compared with that in three comparable series in which renal venous drainage was into the vena cava, nor were the histopathological findings favorably altered in the "portal" kidneys. The injection of semisoluble antigen into the portal vein at the same time as renal transplantation at the caval site, had an effect no different from that if the antigen were given systemically during caval site transplantation. The conclusion that drainage of grafts into the portal vein was not beneficial was reached in 20 pigs evenly divided between the portal and vena caval sites, and in 12 pairs of dog to pig or pig to dog xenografts. Thus, none of these experiments has identified an advantage of antigen delivery into the portal as opposed to the systemic venous system.
将肾脏移植到杂种犬体内，使肾静脉引流进入宿主的门静脉系统。31只接受者未接受治疗，11只接受每千克体重3毫克硫唑嘌呤的单次剂量，11只接受每天2毫克硫唑嘌呤。与三个肾静脉引流至腔静脉的可比系列相比，生存率没有统计学上的提高，“门静脉”肾脏的组织病理学结果也没有得到有利改变。在腔静脉部位进行肾脏移植的同时，将半溶性抗原注入门静脉，其效果与在腔静脉部位移植期间全身给予抗原的效果没有差异。在20只平均分配在门静脉和腔静脉部位的猪以及12对犬到猪或猪到犬的异种移植中，得出移植物引流至门静脉没有益处的结论。因此，这些实验均未发现与全身静脉系统相比，将抗原输送到门静脉有任何优势。
