Castro Ricardo Cardoso, Gonçales Relber Aguiar, Zambuzi Fabiana Albani, Frantz Fabiani Gai
Ribeirão Preto Medical School, University of São Paulo, FMRP/USP, Ribeirão Preto, São Paulo, Brazil.
Immunology and Epigenetics Lab, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-FCFRP/USP, Ribeirão Preto, São Paulo, 14040-903, Brazil.
Inflamm Res. 2021 Mar;70(3):261-274. doi: 10.1007/s00011-021-01442-5. Epub 2021 Feb 9.
The Notch signaling pathway is a cell signaling system that is conserved in a variety of eukaryotes. Overall, Notch receptors and their ligands are single-pass transmembrane proteins, which often require cell-cell interactions and proteolytic processing to promote signaling. Since its discovery, it has been the subject of extensive research that revealed its importance in several cellular mechanisms, including cell fate determination, hematopoiesis, tissue self-renewal, proliferation, and apoptosis during embryogenesis. Many studies have described the influence of the Notch pathway in modulating the innate and adaptive immune systems.
We analyzed the literature on the role of the Notch pathway in regulating immune responses during infections, aiming to discuss the importance of establishing a Notch signaling pathway-based approach for predicting the outcome of infectious diseases.
In this review, we present an overview of evidence that demonstrates the direct and indirect effects of interaction between the Notch signaling pathway and the immune responses against bacterial, viral, fungal, and parasitic infections, as well as the importance of this pathway to predict the outcome of infectious diseases.
Notch信号通路是一种在多种真核生物中保守的细胞信号系统。总体而言，Notch受体及其配体是单次跨膜蛋白，通常需要细胞间相互作用和蛋白水解加工来促进信号传导。自其发现以来，它一直是广泛研究的主题，这些研究揭示了其在多种细胞机制中的重要性，包括胚胎发育过程中的细胞命运决定、造血作用、组织自我更新、增殖和凋亡。许多研究描述了Notch通路在调节固有免疫系统和适应性免疫系统方面的影响。
我们分析了关于Notch通路在感染期间调节免疫反应作用的文献，旨在探讨建立基于Notch信号通路的方法来预测传染病结局的重要性。
在本综述中，我们概述了证据，这些证据证明了Notch信号通路与针对细菌、病毒、真菌和寄生虫感染的免疫反应之间相互作用的直接和间接影响，以及该通路对预测传染病结局的重要性。
