Zhang Zhen-Wu, Ling Di-Yang, Han Jian, Wu Cheng-Xiang, Wang Zhe-Yin
Pain Department, Shenzhen People's Hospital, the 2nd Clinical Medical College of Jinan University, the 1st Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong Province, China.
Zhen Ci Yan Jiu. 2021 Jan 25;46(1):64-8. doi: 10.13702/j.1000-0607.200260.
To observe the clinical efficacy of silver needle heat conduction therapy combined with loxoprofen sodium patch in the treatment of knee osteoarthritis (KOA).
A total of ninety-two patients with KOA were randomly and equally divided into loxoprofen sodium group and silver needle heat conduction therapy + loxoprofen sodium (combination) group, with 46 cases in each group. Patients of the combination group were treated with silver needle heat conduction therapy combined with loxoprofen sodium patch, while those of the loxoprofen sodium group were treated with loxoprofen sodium patch. The treatment was conducted for 4 weeks. The Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), bone metabolism index ［including bone gla protein (BGP), bone-specific alkaline phosphatase (BALP), tartrate resistant acid phosphatase isomer (TRACP)-5b］, and inflammation factors ［including the tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), interleukin-1β (IL-1β)］ were observed before and after treatment. The therapeutic effect was assessed after the treatment.
After the treatment, the total scores of WOMAC, the levels of serum TRACP-5b, TNF-α and IL-1β were significantly decreased (<0.01), while the levels of serum BGP, BALP, and TGF-β were significantly increased (<0.01) in the two groups compared with their own pre-treatment. Silver needle plus loxoprofen sodium was more effective in reducing WOMAC score, TRACP-5b, TNF-α, IL-1β level (<0.01), and up-regulating BGP, BALP, and TGF-β level (<0.01) than loxoprofen. Of the 46 cases in the loxoprofen sodium and combination groups, 33 and 41 were effective, with the effective rate being 71.7% and 89.1%, respectively. The comprehensive therapeutic effect of the combination group was significantly superior to that of the loxoprofen group (<0.05).
Silver needle heat conduction therapy combined with loxoprofen sodium can effectively treat KOA, its mechanism may be related to alleviating inflammation and improving bone metabolism.
观察银质针导热疗法联合洛索洛芬钠贴剂治疗膝骨关节炎（KOA）的临床疗效。
将92例KOA患者随机等分为洛索洛芬钠组和银质针导热疗法+洛索洛芬钠（联合）组，每组46例。联合组患者采用银质针导热疗法联合洛索洛芬钠贴剂治疗，洛索洛芬钠组患者采用洛索洛芬钠贴剂治疗。治疗4周。观察治疗前后西安大略和麦克马斯特大学骨关节炎指数（WOMAC）、骨代谢指标［包括骨钙素（BGP）、骨特异性碱性磷酸酶（BALP）、抗酒石酸酸性磷酸酶异构体（TRACP）-5b］及炎症因子［包括肿瘤坏死因子-α（TNF-α）、转化生长因子-β（TGF-β）、白细胞介素-1β（IL-1β）］。治疗后评估疗效。
治疗后，两组患者WOMAC总分、血清TRACP-5b、TNF-α及IL-1β水平均显著降低（<0.01），血清BGP、BALP及TGF-β水平均显著升高（<0.01）。与洛索洛芬相比，银质针加洛索洛芬钠在降低WOMAC评分、TRACP-5b、TNF-α、IL-1β水平（<0.01）及上调BGP、BALP及TGF-β水平（<0.01）方面更有效。洛索洛芬钠组和联合组46例患者中，有效例数分别为33例和41例，有效率分别为71.7%和89.1%。联合组的综合治疗效果显著优于洛索洛芬钠组（<0.05）。
银质针导热疗法联合洛索洛芬钠可有效治疗KOA，其机制可能与减轻炎症和改善骨代谢有关。
