Department of Vascular Surgery, University Hospital Leipzig, Germany.
Department of Interventional Angiology, University Hospital Leipzig, Germany.
Vasa. 2021 Apr;50(3):186-192. doi: 10.1024/0301-1526/a000937. Epub 2021 Feb 9.
: Our aim was to determine the rate of ischemic stroke following thoracic endovascular aortic repair (TEVAR) after reducing gas volume released during stentgraft deployment by de-airing of thoracic stentgrafts with high-volume of 0.9% heparinized saline solution. : A single center retrospective analysis of all consecutive patients undergoing TEVAR from 2014 to 2019 was performed. All thoracic stentgrafts were flushed with 120 ml 0.9% heparinized saline solution before implantation, according to our institutional protocol. Endpoints were in-hospital rates of ischemic stroke and spinal cord ischemia (SCI), and all-cause mortality. : One hundred and fifty-four patients (mean age: 66.8 ± 13.6 years, 64.9% males) were treated with TEVAR during the study period. Indications for treatment were thoracic aortic aneurysms (n = 75, 48.7%), acute type B aortic dissections (n = 46, 29.9%), aortic arch aneurysms and penetrating aortic ulcers (n = 28, 18.2%), and blunt traumatic aortic injuries (n = 5, 3.2%). Timing of procedure was urgent in 75 patients (48.7%). Proximal landing zone were zone 0-1-2 (n = 75, 48.7%), zone 3 (n = 66, 42.9%) and zone 4 (n = 13, 8.4%). Supra-aortic vessels were revascularized with custom-made fenestrated stentgrafts in 9 patients (5.8%), using chimney technique in 4 patients (2.6%), and with debranching procedures in 19 patients (12.3%). Left subclavian artery was covered without revascularization in 46 patients (29.9%). In-hospital stroke occurred in two patients (1.3%) and SCI in another two patients (1.3%). In-hospital mortality rate was 0.6%. No further in-hospital events were noted. : De-airing of stentgrafts with high-volume of 0.9% heparinized saline solution seems to be safe and can be used as an adjunct to keep occurrence of neurological events after TEVAR as low as possible.
我们的目的是通过用大量 0.9%肝素化生理盐水对胸主动脉腔内修复术(TEVAR)中使用的支架进行去气,以降低支架释放过程中产生的气体量,从而确定支架释放后发生缺血性卒中的比率。
这是一项对 2014 年至 2019 年间连续接受 TEVAR 治疗的所有患者进行的单中心回顾性分析。根据我们的机构方案,所有胸主动脉支架在植入前均用 120ml 0.9%肝素化生理盐水冲洗。主要终点是住院期间缺血性卒中和脊髓缺血(SCI)的发生率以及全因死亡率。
研究期间,154 名患者(平均年龄:66.8±13.6 岁,64.9%为男性)接受了 TEVAR 治疗。治疗指征包括胸主动脉瘤(n=75,48.7%)、急性 B 型主动脉夹层(n=46,29.9%)、主动脉弓动脉瘤和穿透性主动脉溃疡(n=28,18.2%)和钝性创伤性主动脉损伤(n=5,3.2%)。75 名患者(48.7%)的手术时机为紧急。近端着陆区为 0-1-2 区(n=75,48.7%)、3 区(n=66,42.9%)和 4 区(n=13,8.4%)。9 名患者(5.8%)采用定制开窗支架进行了主动脉弓上血管血运重建,4 名患者(2.6%)采用烟囱技术,19 名患者(12.3%)采用去分支技术。46 名患者(29.9%)未行左锁骨下动脉血运重建。住院期间发生卒中 2 例(1.3%),SCI 2 例(1.3%)。住院期间死亡率为 0.6%。无其他住院不良事件发生。
用大量 0.9%肝素化生理盐水对支架进行去气似乎是安全的,可以作为一种辅助手段,使 TEVAR 后神经事件的发生率尽可能低。