Sarkar C, Roy S, Tandon P N
Department of Pathology, All India Institute of Medical Sciences, New Delhi.
Cancer. 1988 May 1;61(9):1862-6. doi: 10.1002/1097-0142(19880501)61:9<1862::aid-cncr2820610923>3.0.co;2-x.
Fifty-five cases of oligodendrogliomas and mixed oligoastrocytomas were evaluated using immunohistochemical (IH) study for glial fibrillary acidic protein (GFAP) and electron microscopic (EM) study. Most of the tumors in both of these groups showed many neoplastic oligodendroglial cells with GFAP-positive staining in their cytoplasm by IH study. By EM study too, many tumor cells showing features of oligodendroglial cells contained intermediate filaments. Our observations suggested the presence of a transitional form of cells in these tumors. The current study supports the contention that both oligodendrogliomas and oligoastrocytomas arise from a common progenitor cell capable of differentiation into both oligodendrocyte and astrocyte. The nature and degree of differentiation depends probably on gene expression and/or some microenvironmental factors.
对55例少突胶质细胞瘤和混合性少突星形细胞瘤进行了免疫组织化学（IH）检测胶质纤维酸性蛋白（GFAP）及电子显微镜（EM）研究。通过IH研究，这两组中的大多数肿瘤在其细胞质中显示出许多GFAP阳性染色的肿瘤性少突胶质细胞。同样通过EM研究，许多具有少突胶质细胞特征的肿瘤细胞含有中间丝。我们的观察结果提示这些肿瘤中存在一种过渡形式的细胞。当前研究支持这样的观点，即少突胶质细胞瘤和少突星形细胞瘤均起源于一种能够分化为少突胶质细胞和星形胶质细胞的共同祖细胞。分化的性质和程度可能取决于基因表达和/或一些微环境因素。
