Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Adv Exp Med Biol. 2021;1290:99-110. doi: 10.1007/978-3-030-55617-4_7.
Interleukin (IL)-24 is a member of the IL-10 family of cytokines. Due to its unique ability to function as both a tumor suppressor and cytokine, IL-24-based cancer therapy has been developed for treating a broad spectrum of human cancers. Majority of the studies reported to date have focused on establishing IL-24 as a cancer therapeutic by primarily focusing on tumor cell killing. However, the ability of IL-24 treatment on modulating the tumor microenvironment and immune response is underinvestigated. In this article, we summarize the biological and functional properties of IL-24 and the benefits of applying IL-24-based therapy for cancer.
白细胞介素 (IL)-24 是白细胞介素 10 家族细胞因子的成员。由于其具有作为肿瘤抑制剂和细胞因子的独特功能，因此已经开发出基于白细胞介素 24 的癌症疗法来治疗广泛的人类癌症。迄今为止，大多数报道的研究都侧重于通过主要关注肿瘤细胞杀伤来确立白细胞介素 24 作为癌症治疗药物的作用。然而，白细胞介素 24 治疗在调节肿瘤微环境和免疫反应方面的能力尚未得到充分研究。在本文中，我们总结了白细胞介素 24 的生物学和功能特性以及应用基于白细胞介素 24 的治疗方法治疗癌症的益处。
