通过钯催化的C(sp)-H官能团化实现八元碳环的非对映选择性构建。
Diastereoselective Construction of Eight-Membered Carbocycles through Palladium-Catalyzed C(sp)-H Functionalization.
作者信息
Wan Bin, Lu Zhuoer, Wu Zhuo, Cheng Cang, Zhang Yanghui
机构信息
School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, 1239 Siping Road, Shanghai, 200092, P. R. China.
出版信息
Org Lett. 2021 Feb 19;23(4):1269-1274. doi: 10.1021/acs.orglett.0c04244. Epub 2021 Feb 9.
A palladium-catalyzed cross-coupling reaction of 2-alkylphenyl bromides with biphenylene has been developed. The reactions formed eight-membered carbocycles through C(sp)-H activation and the formation of two C-C bonds, and the chiral products were obtained with excellent diastereoselectivity. The reaction provides a new strategy for the construction of eight-membered carbocycles, and the products represent a novel type of chiral scaffold.
已开发出一种钯催化的2-烷基苯基溴化物与联亚苯基的交叉偶联反应。该反应通过C(sp)-H活化和形成两个C-C键形成八元碳环，并以优异的非对映选择性获得手性产物。该反应为构建八元碳环提供了一种新策略，且产物代表了一种新型的手性骨架。
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