Ophthalmology Department, University of Health Sciences Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.
Ocul Immunol Inflamm. 2022 May 19;30(4):959-965. doi: 10.1080/09273948.2020.1858117. Epub 2021 Feb 9.
To evaluate the effect of topical omega 3 on ocular surface following corneal crosslinking (CXL) in keratoconus and compare with topical sodium hyaluronate.
50 patients who underwent CXL were divided into two groups. In addition to topical steroids and antibiotics, Group A was prescribed topical omega 3; Group B was prescribed 0.3% sodium hyaluronate. Postoperatively, epithelial defect was measured everyday and at the first month corneal staining, Schirmer test was performed, tear break up time (TBUT), tear meniscus height (TMH) were measured.
Preoperative keratometric values were similar between groups; there was no difference in terms of corneal staining, tear film stability; epithelial closure time (p: 0.052), and postoperative pain scores between groups. At 1st month, TBUT and TMH were significantly better in Group A than Group B(p: 0.001, p: 0.047).
Topical omega 3 increases tear film stability more prominent than sodium hyaluronate following crosslinking.
评估角膜交联（CXL）术后局部使用欧米伽 3 对圆锥角膜眼表的影响，并与局部透明质酸钠进行比较。
50 例接受 CXL 的患者被分为两组。除了局部皮质类固醇和抗生素外，A 组还开了局部欧米伽 3；B 组开了 0.3%透明质酸钠。术后每天测量上皮缺损，并在第一个月进行角膜染色、泪液分泌试验、泪膜破裂时间（TBUT）和泪膜高度（TMH）测量。
两组术前角膜屈光度相似；两组间角膜染色、泪膜稳定性、上皮愈合时间（p：0.052）和术后疼痛评分无差异。术后 1 个月，A 组的 TBUT 和 TMH 明显优于 B 组（p：0.001，p：0.047）。
与透明质酸钠相比，交联术后局部使用欧米伽 3 能更显著地提高泪膜稳定性。
