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帕博利珠单抗治疗伴有 PD-L1 结构变异的蕈样肉芽肿。

Pembrolizumab in mycosis fungoides with PD-L1 structural variants.

机构信息

Division of Medical Oncology, Department of Medicine.

Department of Pathology, and.

出版信息

Blood Adv. 2021 Feb 9;5(3):771-774. doi: 10.1182/bloodadvances.2020002371.

DOI:10.1182/bloodadvances.2020002371
PMID:33560388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7876893/
Abstract

PD-L1 structural variants are recurrent in mycosis fungoides with large cell transformation. PD-L1 structural variants in relapsed/refractory mycosis fungoides should prompt consideration of treatment with PD-1 inhibitors.

摘要

PD-L1 结构变异在大细胞转化蕈样肉芽肿中频繁发生。复发性/难治性蕈样肉芽肿中存在 PD-L1 结构变异时，应考虑使用 PD-1 抑制剂进行治疗。

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本文引用的文献

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The Predictive Value of Tumor Mutation Burden on Efficacy of Immune Checkpoint Inhibitors in Cancers: A Systematic Review and Meta-Analysis.肿瘤突变负荷对癌症中免疫检查点抑制剂疗效的预测价值：一项系统评价和荟萃分析
Front Oncol. 2019 Nov 5;9:1161. doi: 10.3389/fonc.2019.01161. eCollection 2019.
2
Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and Sézary Syndrome: A Multicenter Phase II Study.派姆单抗治疗复发/难治性蕈样霉菌病和塞扎里综合征：一项多中心 II 期研究。
J Clin Oncol. 2020 Jan 1;38(1):20-28. doi: 10.1200/JCO.19.01056. Epub 2019 Sep 18.
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Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas.EB 病毒相关淋巴瘤中频繁涉及程序性死亡配体的结构变异。
Leukemia. 2019 Jul;33(7):1687-1699. doi: 10.1038/s41375-019-0380-5. Epub 2019 Jan 25.
4
Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial.莫格利珠单抗对比伏立诺他治疗既往治疗的皮肤 T 细胞淋巴瘤（MAVORIC）：一项国际性、开放性标签、随机、对照的 3 期临床试验。
Lancet Oncol. 2018 Sep;19(9):1192-1204. doi: 10.1016/S1470-2045(18)30379-6. Epub 2018 Aug 9.
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An Integrated Data Resource for Genomic Analysis of Cutaneous T-Cell Lymphoma.皮肤T细胞淋巴瘤基因组分析的综合数据资源
J Invest Dermatol. 2018 Dec;138(12):2681-2683. doi: 10.1016/j.jid.2018.06.176. Epub 2018 Jul 5.
6
Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).对220例皮肤T细胞淋巴瘤（CTCL）进行的基因组分析确定了RLTPR（p.Q575E）中一种新的复发性功能获得性改变。
Blood. 2017 Sep 21;130(12):1430-1440. doi: 10.1182/blood-2017-02-768234. Epub 2017 Jul 10.
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Nat Genet. 2015 Dec;47(12):1465-70. doi: 10.1038/ng.3442. Epub 2015 Nov 9.