大剂量静脉注射甲基强的松龙和环磷酰胺对同种异体肾移植的影响。
Effect of high doses of intravenous methylprednisolone and cyclophosphamide on renal homografts.
作者信息
Zincke H, Woods J E, Holley K E
出版信息
Urology. 1977 Oct;10(4):301-4. doi: 10.1016/0090-4295(77)90154-6.
PMID:335605
Abstract
The intravenous administration of high doses of methylprednisolone and cyclophosphamide during pretreatment of the heart-beating canine and human cadaveric allograft donor has caused no observable adverse effect on renal allografts. This is in contrast to that noted when high doses of these drugs are added to the preservation perfusate in which they are not metabolized and may possibly cause renal damage.
摘要
在对心跳状态下的犬类和人类尸体同种异体移植供体进行预处理期间静脉注射高剂量甲泼尼龙和环磷酰胺，对肾移植没有观察到明显的不良影响。这与将高剂量这些药物添加到保存灌注液中时的情况形成对比，在灌注液中它们不会被代谢，可能会导致肾损伤。
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