Department of Nuclear Medicine, Başakşehir Çam and Sakura City Hospital, İstanbul.
Departments of Nuclear Medicine.
Nucl Med Commun. 2021 May 1;42(5):503-509. doi: 10.1097/MNM.0000000000001370.
The aim of this study was to investigate the relationship between volumetric data obtained from staging 68Ga-prostate-specific membrane antigen (PSMA) PET computerized tomography (CT) images with prostate-specific antigen (PSA), risk groups, Gleason Grade (GG) groups and presence of metastasis.
We performed a retrospective analysis of 68Ga-PSMA PET-CT images from 88 patients undergoing initial staging of prostate adenocarcinoma between January 2015 and September 2018. Images were evaluated in LIFEx software; PSMA involvement above the background activity in prostate gland, lymph node and other distant metastases was plotted with 40% SUVmax threshold, SUVmax, PSMA tumor volume (PSMA-TV) and total lesion PSMA (TL-PSMA) values were obtained.
In all patients, there was a moderate correlation between PSA and PSMA-tumor volume whole-body (PSMA-TVwb) (P < 0.001, r = 0.580) and a high correlation between total lesion-PSMAwb (TL-PSMAwb) (P < 0.001, r = 0.636). Prostate PSMA-TV (PSMA-TVp) and TL-PSMA (PSMA-TVp) values were different in local and locally advanced/metastatic patients (P = 0.020 and 0.006, respectively). PSMA-TVp and TL-PSMAp values were significantly different in low-moderate and high-risk patients (P = 0.003 and <0.001, respectively), and in patients with and without metastasis (P = 0.008 and <0.001, respectively). PSMA-TVp, PSMA-TVwb, TL-PSMAp and TL-PSMAwb values were significantly different in patients with GG ≤3 and >3 (P = 0.030, 0.002, <0.001 and <0.001, respectively).
Pretreatment 68Ga-PSMA PET/CT volumetric parameters provides unique data to use in the clinical decision-making process of patients with adenocarcinoma of the prostate.
本研究旨在探讨 68Ga-前列腺特异性膜抗原（PSMA）PET 计算机断层扫描（CT）图像容积数据与前列腺特异性抗原（PSA）、危险分组、Gleason 分级（GG）组和转移存在之间的关系。
我们对 2015 年 1 月至 2018 年 9 月间 88 例前列腺腺癌初始分期接受 68Ga-PSMA PET-CT 检查的患者进行了回顾性分析。图像在 LIFEx 软件中进行评估；采用 40%SUVmax 阈值绘制前列腺、淋巴结和其他远处转移中 PSMA 活性以上的摄取情况，并获取 PSMA 肿瘤体积（PSMA-TV）和总病变 PSMA（TL-PSMA）值。
在所有患者中，PSA 与全身 PSMA 肿瘤体积（PSMA-TVwb）之间存在中度相关性（P<0.001，r=0.580），与总病变 PSMAwb（TL-PSMAwb）之间存在高度相关性（P<0.001，r=0.636）。局部和局部进展/转移患者的前列腺 PSMA-TV（PSMA-TVp）和 TL-PSMA（PSMA-TVp）值不同（P=0.020 和 0.006）。低危和高危患者的 PSMA-TVp 和 TL-PSMAp 值差异显著（P=0.003 和 <0.001），有转移和无转移患者的 PSMA-TVp 和 TL-PSMAp 值差异显著（P=0.008 和 <0.001）。GG≤3 和>3 患者的 PSMA-TVp、PSMA-TVwb、TL-PSMAp 和 TL-PSMAwb 值差异显著（P=0.030、0.002、<0.001 和 <0.001）。
68Ga-PSMA PET/CT 容积参数为前列腺腺癌患者的临床决策提供了独特的数据。
