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alpha 酮戊酸对雌性恒河猴运动体感诱发电位的影响（）。

Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque ().

机构信息

University Biomedical Services, University of Cambridge, UK.

Faculty of Life Science and Medicine, King's College London, UK.

出版信息

Lab Anim. 2021 Aug;55(4):363-366. doi: 10.1177/0023677221990706. Epub 2021 Feb 9.

DOI:10.1177/0023677221990706
PMID:33560908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8361466/
Abstract

This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine.

摘要

本通讯报道了阿尔法羟酮对恒河猴运动体感诱发电位（SEP）的影响。动物用氯胺酮、美托咪定、咪达唑仑和阿芬太尼输注进行深度麻醉。刺激正中神经，从运动皮层记录 SEP。连续给予三剂阿尔法羟酮（0.5、1 和 2 mg/kg）诱导潜伏期时间延长和 SEP 幅度降低。然而，波形结构保持不变，因此阿尔法羟酮可能是神经科学研究以及兽医或人类医学中合适的全身麻醉选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b4/8361466/9d3ab65371a4/10.1177_0023677221990706-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b4/8361466/9d3ab65371a4/10.1177_0023677221990706-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67b4/8361466/9d3ab65371a4/10.1177_0023677221990706-fig1.jpg

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