Fujimoto Manabu
Department of Dermatology, Graduate School of Medicine Osaka University.
Brain Nerve. 2021 Feb;73(2):137-146. doi: 10.11477/mf.1416201726.
Dermatomyositis and antisynthetase syndrome are among idiopathic inflammatory myopathies (myositis) that have skin lesions. In these disorders, skin symptoms often appear as the initial manifestations, and thus, their evaluation is critical for diagnosis. Two components, "site" and "properties," are important for understanding the skin manifestations in myositis. The rash in these disorders is induced by Koebner's phenomenon, and is most frequently observed on the hands and face. Recent studies have shown that myositis-specific autoantibodies are useful tools for the diagnosis and classification of these diseases, as they are closely correlated with the clinical and histopathological phenotypes of myositis. It has recently become clear that each antibody is associated with characteristic skin manifestations, especially related to the properties of the skin lesions.
皮肌炎和抗合成酶综合征属于伴有皮肤病变的特发性炎性肌病（肌炎）。在这些疾病中，皮肤症状常为首发表现，因此，对其进行评估对于诊断至关重要。“部位”和“特征”这两个要素对于理解肌炎中的皮肤表现很重要。这些疾病中的皮疹由同形反应诱发，最常见于手部和面部。最近的研究表明，肌炎特异性自身抗体是这些疾病诊断和分类的有用工具，因为它们与肌炎的临床和组织病理学表型密切相关。最近已经明确，每种抗体都与特征性皮肤表现相关，尤其是与皮肤病变的特征有关。
