Guru Gobind Singh College of Pharmacy, Yamuna Nagar 135001, Haryana, India.
Recent Pat Anticancer Drug Discov. 2021;16(2):249-257. doi: 10.2174/1574892816666210208230848.
Polymers are used in drug delivery systems to encapsulate and release the drug. Natural polymers have the advantages of biodegradability, biocompatibility, and recognizable biological moieties that maintain cellular functions as compared to synthetic polymers. Chitosan is a natural polycationic linear polysaccharide that originates from chitin. Its easy modification, release rate of drug, ability to cross-link with other polymers, gelling ability, immunostimulation, bioadhesion, biocompatibility, and biodegradability has increased its application in various drug delivery systems.
The objective of the present study is to overview the recent patents of the application of chitosan in various drug delivery systems and their use in the prevention of cancer and other ailments.
In this review, the patent application of chitosan in various drug delivery systems employed to cure mainly cancer has been covered with particular emphasis on their scientific impact and novelty.
Chitosan has proved its potential as a polymer to control and target the drug at the site of action.
The potential of chitosan and its derivatives to deliver and target the drug may open new avenues for therapeutic interventions in different tumors.
聚合物被用于药物传递系统中，以包裹和释放药物。与合成聚合物相比，天然聚合物具有生物降解性、生物相容性和可识别的生物部分的优点，能够维持细胞功能。壳聚糖是一种天然的阳离子线性多糖，来源于几丁质。它易于修饰、药物释放速度快、能够与其他聚合物交联、具有凝胶能力、免疫刺激、生物黏附性、生物相容性和生物降解性，这增加了它在各种药物传递系统中的应用。
本研究的目的是综述壳聚糖在各种药物传递系统中的应用专利及其在预防癌症和其他疾病方面的应用。
在本次综述中，涵盖了壳聚糖在各种药物传递系统中的专利申请，主要集中在治疗癌症方面，并特别强调了它们的科学影响和新颖性。
壳聚糖已被证明具有作为聚合物控制和靶向作用部位药物的潜力。
壳聚糖及其衍生物在递药和靶向药物方面的潜力可能为不同肿瘤的治疗干预开辟新途径。
