Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Anticancer Agents Med Chem. 2021;21(17):2315-2326. doi: 10.2174/1871520621666210201100326.
Hypoxia pathway and aberrant miRNA expression profile play crucial roles in the development of various cancers. Recent studies have emphasized that there are many collaborations in this cases because both of them are involved in cancer cell processes, including differentiation, metastasis, and cell proliferation and signaling pathways. Further studies have elucidated that miRNAs affect the hypoxia route, and more interestingly, the hypoxia pathway also affects miRNAs expression profile. The literature review summarizes the fundamental roles of hypoxia-related miRNAs in different cancers. The mutual interactions between miRNAs and hypoxia are a new layer of complexity in cancer hypoxia, which might be helpful in controlling cancer progression. It is also possible that the hypoxia pathway is initiated by miRNAs. In contrast, the hypoxia pathway regulates the expression of a large group of miRNAs. In this review for the first time, we discussed the significant interactions between hypoxia and miRNAs in order to determine new perspectives for new therapeutic aims in the field of cancer.
缺氧途径和异常的 miRNA 表达谱在各种癌症的发展中起着关键作用。最近的研究强调，在这些情况下有许多协作，因为它们都参与了癌细胞的过程，包括分化、转移以及细胞增殖和信号通路。进一步的研究阐明了 miRNAs 影响缺氧途径，更有趣的是，缺氧途径也影响 miRNA 的表达谱。文献综述总结了与缺氧相关的 miRNAs 在不同癌症中的基本作用。miRNAs 和缺氧之间的相互作用是癌症缺氧的一个新的复杂性层次，这可能有助于控制癌症的进展。也有可能是 miRNAs 启动了缺氧途径。相反，缺氧途径调节一大组 miRNA 的表达。在这篇综述中，我们首次讨论了缺氧和 miRNAs 之间的重要相互作用，以便为癌症领域的新治疗目标确定新的视角。
