The National Institute for Health Research Applied Research Collaboration West (NIHR ARC West) at University Hospitals Bristol National Health Service Foundation Trust, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Int J Behav Nutr Phys Act. 2021 Feb 10;18(1):22. doi: 10.1186/s12966-021-01082-2.
Randomised controlled trials (RCTs) are often regarded as the gold standard of evidence, and subsequently go on to inform policymaking. Cochrane Reviews synthesise this type of evidence to create recommendations for practice, policy, and future research. Here, we critically appraise the RCTs included in the childhood obesity prevention Cochrane Review to understand the focus of these interventions when examined through a wider determinants of health (WDoH) lens.
We conducted a secondary analysis of the interventions included in the Cochrane Review on "Interventions for Preventing Obesity in Children", published since 1993. All 153 RCTs were independently coded by two authors against the WDoH model using an adaptive framework synthesis approach. We used aspects of the Action Mapping Tool from Public Health England to facilitate our coding and to visualise our findings against the 226 perceived causes of obesity.
The proportion of interventions which targeted downstream (e.g. individual and family behaviours) as opposed to upstream (e.g. infrastructure, environmental, policy) determinants has not changed over time (from 1993 to 2015), with most intervention efforts (57.9%) aiming to change individual lifestyle factors via education-based approaches. Almost half of the interventions (45%) targeted two or more levels of the WDoH. Where interventions targeted some of the wider determinants, this was often achieved via upskilling teachers to deliver educational content to children. No notable difference in design or implementation was observed between interventions targeting children of varying ages (0-5 years, 6-12 years, 13-18 years).
This study highlights that interventions, evaluated via RCTs, have persisted to focus on downstream, individualistic determinants of obesity over the last 25 years, despite the step change in our understanding of its complex aetiology. We hope that the findings from our analysis will challenge research funders, researchers, policymakers and practitioners to reflect upon, and critique, the evidence-based paradigm in which we operate, and call for a shift in focus of new evidence which better accounts for the complexity of obesity.
随机对照试验(RCT)通常被视为证据的金标准,并随后为决策提供依据。Cochrane 综述综合了此类证据,为实践、政策和未来研究提出建议。在这里,我们批判性地评估了纳入儿童肥胖预防 Cochrane 综述的 RCT,以了解通过更广泛的健康决定因素(WDoH)视角检查这些干预措施的重点。
我们对自 1993 年以来发表的关于“预防儿童肥胖的干预措施”的 Cochrane 综述中纳入的干预措施进行了二次分析。所有 153 项 RCT 均由两位作者独立使用适应性框架综合方法根据 WDoH 模型进行编码。我们使用英国公共卫生部门的行动映射工具的各个方面来促进我们的编码,并根据 226 个肥胖的潜在原因来可视化我们的发现。
针对下游(例如个人和家庭行为)而非上游(例如基础设施、环境、政策)决定因素的干预措施的比例在过去的时间里并没有改变(从 1993 年到 2015 年),大多数干预措施(57.9%)旨在通过基于教育的方法改变个人生活方式因素。几乎一半的干预措施(45%)针对 WDoH 的两个或更多层次。针对更广泛的决定因素的干预措施通常是通过提高教师的技能来向儿童传授教育内容来实现的。针对不同年龄段的儿童(0-5 岁、6-12 岁、13-18 岁)的干预措施在设计或实施方面没有明显差异。
本研究表明,尽管我们对其复杂病因的理解发生了重大变化,但通过 RCT 评估的干预措施在过去 25 年中一直专注于肥胖的下游、个人决定因素,而没有关注其他方面。我们希望我们的分析结果将挑战研究资助者、研究人员、政策制定者和实践者,促使他们反思和批评我们所依据的循证范式,并呼吁将重点转移到新的证据上,这些证据更好地解释了肥胖的复杂性。