Yasko Jessica R, Mains Richard E
Department of Neuroscience, University of Connecticut Health Center, Farmington CT 06030-3401, USA.
Trends Cell Mol Biol. 2018;13:67-84.
Traumatic spinal cord injury (SCI) has devastating implications for patients, including a high prevalence of chronic pain. Despite advancements in our understanding of the mechanisms involved post-SCI, there are no effective treatments for chronic pain following injury. The development of new treatment interventions for pain is needed, but this requires improved models to assess injury-related cellular, neurophysiological and molecular changes in the spinal cord. Here, we will discuss recent animal models for SCI, molecular screening for altered patterns of gene expression, and the importance of injury severity and timing after SCI.
创伤性脊髓损伤（SCI）对患者具有毁灭性影响，包括慢性疼痛的高患病率。尽管我们对脊髓损伤后所涉及的机制的理解有所进步，但对于损伤后的慢性疼痛尚无有效治疗方法。需要开发新的疼痛治疗干预措施，但这需要改进模型来评估脊髓中与损伤相关的细胞、神经生理和分子变化。在此，我们将讨论近期的脊髓损伤动物模型、基因表达改变模式的分子筛选，以及脊髓损伤后损伤严重程度和时间的重要性。
